| Tag | Content |
|---|
| CPLM ID | CPLM-016061 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine/threonine-protein phosphatase 1 regulatory subunit 10 |
Protein Synonyms/Alias | MHC class I region proline-rich protein CAT53 |
Gene Name | Ppp1r10 |
Gene Synonyms/Alias | Cat53; Pnuts |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 491 | YIQAEREKGILQELF | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers. |
Sequence Annotation | DOMAIN 73 147 TFIIS N-terminal.
ZN_FING 854 882 C3H1-type.
REGION 1 348 Interaction with TOX4.
REGION 382 450 Essential for PPP1CA inhibition (By
REGION 388 417 Necessary for interaction with PPP1CA.
REGION 393 408 Necessary for interaction with PPP1CC (By
REGION 418 619 Interaction with WDR82.
MOTIF 420 423 PP1-binding motif.
MOD_RES 313 313 Phosphoserine.
MOD_RES 398 398 Phosphothreonine (By similarity).
MOD_RES 400 400 Phosphothreonine (By similarity).
MOD_RES 591 591 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Protein phosphatase inhibitor; Reference proteome; RNA-binding; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 888 AA |
Protein Sequence | MGSGPIDPKE LLKGLDSFLT RDGEVKSVDG ISKIFSLMKE ARKMVSRCTY LNIILQTRAP 60
EVLVKFIDVG GYKLLNNWLT YSKTTNNIPL LQQILLTLQH LPLTVDHLKQ NNTAKLVKQL 120
SKSSEDEELR KLASVLVSDW MAVIRSQSST QPAEKDKKKR KEEGKSRTTL PERPLTEVKA 180
ETRAEEAPEK KKEKPKSLRT TAPSHAKFRS TGLELDTPSL VPVKKNSSTV VVSDKYNLKP 240
IPLKRQSATA APGDAAPPAE KKYKPLNTAP NTTKEIKVKI IPPQPMEGLG FLDALNSAPV 300
PGIKIKKKKK VLSPTAAKPS PFEGKTSTEQ STAKPSSPEP APPAEPMDTD RPGTPVPPVE 360
VPELMDAASS EPGALDAKPV DSPGDPNQLT RKGRKRKTVT WPEEGKLREY FYFELDETER 420
VNVNKIKDFG EAAKREILSD RHAFETARRL SHDNMEEKVP WVCPRPLVLP SPLVIPGSNS 480
QERYIQAERE KGILQELFLN KESPHEPDPE PYEPIPPKLI PLDEECAMDE TPYVETLEPG 540
GSGGSPDGAG GSKLPPVLAN LMGSMGAGKS PQGPGGGGIN VQEILTSIMG SPNSHPSEEL 600
LKQPDYSDKL KQMLVPHGLL GPGPVANGFP PGGPGGPKGM QHFPPGPGGP MPGPHGGPGG 660
PVGPRLLGPP PPSRGGDPFW DGPGDPMRGG PMRGGPGPAP GPYHRGRGGR GGNEPPPPPP 720
FRGARGGRSG GGPPNGRGGP GGGGMVGGGG HRPHEGPGGS MGSGHRSHDG PGGNMGSGHR 780
SHDGPGGNMG GSGGHRSHEG PGHGGPHGHR PHDVPSHRGH DHRGPPPHEH RGHDGHGGGG 840
HRGHDGGHSH GGDMSNRPVC RHFMMKGNCR YENNCAFYHP GVNGPPLP 888 |
Gene Ontology | GO:0000785; C:chromatin; IDA:UniProtKB. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0072357; C:PTW/PP1 phosphatase complex; IDA:UniProtKB. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006351; P:transcription, DNA-dependent; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |