UniProt Accession

 LEG3_MOUSE; P16110 

Genbank Protein ID

 X16834; J03723; X16074 

Genbank Nucleotide ID

 CAA34736.1; AAA37311.1; CAA34206.1 

Protein Name

 Galectin-3 

Protein Synonyms/Alias

 Gal-3; 35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; Galactose-specific lectin 3; IgE-binding protein; L-34 galactoside-binding lectin; Laminin-binding protein; Lectin L-29; Mac-2 antigen 

Gene Name

 Lgals3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
197	KQDNNWGKEERQSAF	acetylation	[1]
210	AFPFESGKPFKIQVL	acetylation	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells (By similarity). 

Sequence Annotation

 REPEAT 35 43 1.
 REPEAT 44 52 2.
 REPEAT 53 61 3.
 REPEAT 62 70 4.
 REPEAT 71 79 5.
 REPEAT 80 88 6.
 REPEAT 89 97 7.
 REPEAT 98 107 8.
 REPEAT 108 114 9; truncated.
 DOMAIN 132 262 Galectin.
 REGION 35 114 9 X 9 AA tandem repeats of Y-P-G-X(3)-P-
 REGION 195 201 Beta-galactoside binding (By similarity).
 MOTIF 240 255 Nuclear export signal.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 6 6 Phosphoserine; by CK1 (By similarity).
 DISULFID 187 187 Interchain.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Differentiation; Direct protein sequencing; Disulfide bond; IgE-binding protein; Immunity; Innate immunity; Lectin; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Secreted; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 264 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005578; C:proteinaceous extracellular matrix; IDA:MGI.
 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0030198; P:extracellular matrix organization; IGI:MGI.
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
 GO:0001501; P:skeletal system development; IGI:MGI. 

Interpro

 IPR008985; ConA-like_lec_gl_sf.
 IPR013320; ConA-like_subgrp.
 IPR015534; Galectin_3.
 IPR001079; Galectin_CRD. 

Pfam

 PF00337; Gal-bind_lectin 

SMART

 SM00908; Gal-bind_lectin
 SM00276; GLECT 

PROSITE

 PS51304; GALECTIN 

PRINTS