| Tag | Content |
|---|
| CPLM ID | CPLM-014271 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Epidermal growth factor receptor substrate 15-like 1 |
Protein Synonyms/Alias | Epidermal growth factor receptor pathway substrate 15-related sequence; Eps15-rs; Eps15-related protein; Eps15R |
Gene Name | Eps15l1 |
Gene Synonyms/Alias | Eps15-rs; Eps15R |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 490 | QSQESDLKSQEDDLN | ubiquitination | [1] | | 532 | ETILRSLKCTQDDIN | ubiquitination | [1] | | 544 | DINQARSKLSQLQES | ubiquitination | [1] | | 600 | GAMDDPFKNKALLFS | ubiquitination | [1] | | 602 | MDDPFKNKALLFSNN | ubiquitination | [1] | | 630 | PFKSDPFKGADPFKG | ubiquitination | [1] | | 692 | FTSDPFTKNPSLPSK | ubiquitination | [1] | | 699 | KNPSLPSKLDPFESS | ubiquitination | [1] | | 827 | GDPFQNKKGFGDPFS | ubiquitination | [1] | | 836 | FGDPFSGKDPFAPSS | ubiquitination | [1] | | 846 | FAPSSSAKPPKTSSS | ubiquitination | [1] | | 849 | SSSAKPPKTSSSGFA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2 (By similarity). |
Sequence Annotation | DOMAIN 15 104 EH 1.
DOMAIN 127 215 EH 2.
DOMAIN 159 194 EF-hand.
DOMAIN 273 363 EH 3.
REPEAT 863 882 UIM 1.
REPEAT 889 907 UIM 2.
REGION 15 368 Interaction with DAB2.
MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 9 9 Phosphoserine.
MOD_RES 30 30 Phosphotyrosine.
MOD_RES 31 31 Phosphothreonine.
MOD_RES 74 74 Phosphotyrosine.
MOD_RES 229 229 Phosphoserine.
MOD_RES 238 238 Phosphoserine.
MOD_RES 244 244 Phosphoserine.
MOD_RES 250 250 Phosphoserine.
MOD_RES 255 255 Phosphoserine.
MOD_RES 353 353 Phosphoserine.
MOD_RES 364 364 Phosphothreonine.
MOD_RES 558 558 Phosphoserine (By similarity).
MOD_RES 795 795 Phosphothreonine (By similarity). |
Keyword | Acetylation; Alternative splicing; Calcium; Cell membrane; Coated pit; Coiled coil; Complete proteome; Endocytosis; Membrane; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 907 AA |
Protein Sequence | MAAPLVPLSQ QIPGGNPLYE SYYKQVDPAY TGRVGASEAA LFLKKSGLSD IILGKIWDLA 60
DPEGKGFLDK QGFYVALRLV ACAQSGHEVT LSSLSLTMPP PKFHDTSSPL MATQSSAETH 120
WAVRVEEKAK FDGIFESLLP VNGLLSGDKV KPVLMNSKLP LDVLGRVWDL SDIDKDGHLD 180
RDEFAVAMHL VYRALEKEPV PSILPPPLIP PSKRKKTVFA GAVPVLPASP PPKDSLRSTP 240
SHGSVSSLNS TGSLSPKHSV KQPPVAWVVP VADKMRFDEI FLKTDLDLDG YVSGQEVKEI 300
FMHSGLTQNL LAHIWALADT RQTGKLSKEQ FALAMYFIQQ KVSKGIDPPQ VLSPDMVPPS 360
ERGTPIPDSS STLASGEFTG VKELDDISQE IAQLQREKYS LEQDIREKEE AIRQKTSEVQ 420
ELQNDLDRET SSLQELEAQK QDAQDRLDEM DQQKAKLRDM LSDVRQKCQD ETQTISSLKT 480
QIQSQESDLK SQEDDLNRAK SELNRLQQEE TQLEQSIQAG RAQLETILRS LKCTQDDINQ 540
ARSKLSQLQE SHLEAHRSLE QYDQVPDGVS GTSLPDLATL NEGILLAERG GFGAMDDPFK 600
NKALLFSNNS QELHPDPFQA EDPFKSDPFK GADPFKGDPF QSDPFSEQQT AATDPFGGDP 660
FKESDPFHSS SSDDFFKKQT KNDPFTSDPF TKNPSLPSKL DPFESSDPFS SSSISSKGSD 720
PFGTLDPFGS SSFSSAEGFA DFSQMSKPPP SGPFSSSLGG TGFSDDPFKS KQDTPALPPK 780
KPAPPRPKPP SGQSTPVSQL GSSDFPESPD PFQPLGADSG DPFQNKKGFG DPFSGKDPFA 840
PSSSAKPPKT SSSGFADFTS FGNEEQQLAW AKRESEKAEQ ERLARLRRQE QEDLELAIAL 900
SKADMPA 907 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |