CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012180
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein patched homolog 1 
Protein Synonyms/Alias
 PTC; PTC1 
Gene Name
 PTCH1 
Gene Synonyms/Alias
 PTCH 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
163QLMIQTPKEEGANVLubiquitination[1]
904IDISQLTKQRLVDADubiquitination[1]
993DFVEAIEKVRTICSNubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. 
Sequence Annotation
 DOMAIN 438 598 SSD.
 CARBOHYD 141 141 N-linked (GlcNAc...) (Potential).
 CARBOHYD 312 312 N-linked (GlcNAc...) (Potential).
 CARBOHYD 349 349 N-linked (GlcNAc...) (Potential).
 CARBOHYD 414 414 N-linked (GlcNAc...) (Potential).
 CARBOHYD 875 875 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1000 1000 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Disease mutation; Glycoprotein; Holoprosencephaly; Membrane; Polymorphism; Receptor; Reference proteome; Transmembrane; Transmembrane helix; Tumor suppressor. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1447 AA 
Protein Sequence
MASAGNAAEP QDRGGGGSGC IGAPGRPAGG GRRRRTGGLR RAAAPDRDYL HRPSYCDAAF 60
ALEQISKGKA TGRKAPLWLR AKFQRLLFKL GCYIQKNCGK FLVVGLLIFG AFAVGLKAAN 120
LETNVEELWV EVGGRVSREL NYTRQKIGEE AMFNPQLMIQ TPKEEGANVL TTEALLQHLD 180
SALQASRVHV YMYNRQWKLE HLCYKSGELI TETGYMDQII EYLYPCLIIT PLDCFWEGAK 240
LQSGTAYLLG KPPLRWTNFD PLEFLEELKK INYQVDSWEE MLNKAEVGHG YMDRPCLNPA 300
DPDCPATAPN KNSTKPLDMA LVLNGGCHGL SRKYMHWQEE LIVGGTVKNS TGKLVSAHAL 360
QTMFQLMTPK QMYEHFKGYE YVSHINWNED KAAAILEAWQ RTYVEVVHQS VAQNSTQKVL 420
SFTTTTLDDI LKSFSDVSVI RVASGYLLML AYACLTMLRW DCSKSQGAVG LAGVLLVALS 480
VAAGLGLCSL IGISFNAATT QVLPFLALGV GVDDVFLLAH AFSETGQNKR IPFEDRTGEC 540
LKRTGASVAL TSISNVTAFF MAALIPIPAL RAFSLQAAVV VVFNFAMVLL IFPAILSMDL 600
YRREDRRLDI FCCFTSPCVS RVIQVEPQAY TDTHDNTRYS PPPPYSSHSF AHETQITMQS 660
TVQLRTEYDP HTHVYYTTAE PRSEISVQPV TVTQDTLSCQ SPESTSSTRD LLSQFSDSSL 720
HCLEPPCTKW TLSSFAEKHY APFLLKPKAK VVVIFLFLGL LGVSLYGTTR VRDGLDLTDI 780
VPRETREYDF IAAQFKYFSF YNMYIVTQKA DYPNIQHLLY DLHRSFSNVK YVMLEENKQL 840
PKMWLHYFRD WLQGLQDAFD SDWETGKIMP NNYKNGSDDG VLAYKLLVQT GSRDKPIDIS 900
QLTKQRLVDA DGIINPSAFY IYLTAWVSND PVAYAASQAN IRPHRPEWVH DKADYMPETR 960
LRIPAAEPIE YAQFPFYLNG LRDTSDFVEA IEKVRTICSN YTSLGLSSYP NGYPFLFWEQ 1020
YIGLRHWLLL FISVVLACTF LVCAVFLLNP WTAGIIVMVL ALMTVELFGM MGLIGIKLSA 1080
VPVVILIASV GIGVEFTVHV ALAFLTAIGD KNRRAVLALE HMFAPVLDGA VSTLLGVLML 1140
AGSEFDFIVR YFFAVLAILT ILGVLNGLVL LPVLLSFFGP YPEVSPANGL NRLPTPSPEP 1200
PPSVVRFAMP PGHTHSGSDS SDSEYSSQTT VSGLSEELRH YEAQQGAGGP AHQVIVEATE 1260
NPVFAHSTVV HPESRHHPPS NPRQQPHLDS GSLPPGRQGQ QPRRDPPREG LWPPPYRPRR 1320
DAFEISTEGH SGPSNRARWG PRGARSHNPR NPASTAMGSS VPGYCQPITT VTASASVTVA 1380
VHPPPVPGPG RNPRGGLCPG YPETDHGLFE DPHVPFHVRC ERRDSKVEVI ELQDVECEER 1440
PRGSSSN 1447 
Gene Ontology
 GO:0005901; C:caveola; IDA:BHF-UCL.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:BHF-UCL.
 GO:0030496; C:midbody; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
 GO:0015485; F:cholesterol binding; IDA:BHF-UCL.
 GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
 GO:0008201; F:heparin binding; IEA:Compara.
 GO:0007420; P:brain development; ISS:BHF-UCL.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Compara.
 GO:0061005; P:cell differentiation involved in kidney development; IEA:Compara.
 GO:0072203; P:cell proliferation involved in metanephros development; IEA:Compara.
 GO:0071397; P:cellular response to cholesterol; IMP:BHF-UCL.
 GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Compara.
 GO:0009953; P:dorsal/ventral pattern formation; ISS:UniProtKB.
 GO:0030326; P:embryonic limb morphogenesis; ISS:UniProtKB.
 GO:0008544; P:epidermis development; IEA:Compara.
 GO:0042593; P:glucose homeostasis; IEA:Compara.
 GO:0003007; P:heart morphogenesis; IEA:Compara.
 GO:0035137; P:hindlimb morphogenesis; IEA:Compara.
 GO:0043616; P:keratinocyte proliferation; IEA:Compara.
 GO:0060603; P:mammary gland duct morphogenesis; IEA:Compara.
 GO:0060644; P:mammary gland epithelial cell differentiation; IEA:Compara.
 GO:0051782; P:negative regulation of cell division; IEA:Compara.
 GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Compara.
 GO:0040015; P:negative regulation of multicellular organism growth; ISS:UniProtKB.
 GO:0045668; P:negative regulation of osteoblast differentiation; IMP:BHF-UCL.
 GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IMP:BHF-UCL.
 GO:0045879; P:negative regulation of smoothened signaling pathway; ISS:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:0021997; P:neural plate axis specification; ISS:BHF-UCL.
 GO:0001843; P:neural tube closure; IEA:Compara.
 GO:0021532; P:neural tube patterning; IMP:BHF-UCL.
 GO:0009887; P:organ morphogenesis; ISS:UniProtKB.
 GO:0060037; P:pharyngeal system development; IMP:BHF-UCL.
 GO:0010875; P:positive regulation of cholesterol efflux; IDA:BHF-UCL.
 GO:0016485; P:protein processing; ISS:UniProtKB.
 GO:0072661; P:protein targeting to plasma membrane; IDA:BHF-UCL.
 GO:0007346; P:regulation of mitotic cell cycle; IEA:Compara.
 GO:0032880; P:regulation of protein localization; IEA:Compara.
 GO:0072001; P:renal system development; IEP:UniProtKB.
 GO:0010157; P:response to chlorate; IEA:Compara.
 GO:0007224; P:smoothened signaling pathway; IEP:UniProtKB.
 GO:0061053; P:somite development; IMP:BHF-UCL. 
Interpro
 IPR003392; Patched.
 IPR000731; SSD.
 IPR004766; TM_rcpt_patched. 
Pfam
 PF02460; Patched 
SMART
  
PROSITE
 PS50156; SSD 
PRINTS