CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030361
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histidine ammonia-lyase 
Protein Synonyms/Alias
  
Gene Name
 Hal 
Gene Synonyms/Alias
 mCG_4802 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
37EAVRRYMKNKPDNGGubiquitination[1]
39VRRYMKNKPDNGGFTubiquitination[1]
112SKYREPEKYIALDGDubiquitination[1]
131EDLVNLGKGRYKIKLubiquitination[1]
137GKGRYKIKLTSIAEKubiquitination[1]
158EVIDSIIKERTVVYGubiquitination[1]
172GITTGFGKFARTVIPubiquitination[1]
182RTVIPANKLQELQVNubiquitination[1]
200SHSSGVGKPLSPERCubiquitination[1]
220LRINVLAKGYSGISLubiquitination[1]
277EGKMWSPKSGWADAKubiquitination[1]
293VLEAHGLKPIVLKPKubiquitination[1]
298GLKPIVLKPKEGLALubiquitination[1]
300KPIVLKPKEGLALINubiquitination[1]
342ALTLEVLKGTTKAFDubiquitination[1]
346EVLKGTTKAFDTDIHubiquitination[1]
578KTTTPLEKVYDLVRSubiquitination[1]
592SVVRPWIKDRFMAPDubiquitination[1]
611HRLLLDQKVWEVAAPubiquitination[1]
622VAAPYIEKYRMEHIPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Histidine metabolism; Lyase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 657 AA 
Protein Sequence
MPRYTVHVRG EWLAVPCQDG KLTVGWLGRE AVRRYMKNKP DNGGFTSVDE VQFLVHRCKG 60
LGLLDNEDEL EVALEDNEFV EVVIEGDVMS PDFIPSQPEG VFLYSKYREP EKYIALDGDS 120
LSTEDLVNLG KGRYKIKLTS IAEKKVQQSR EVIDSIIKER TVVYGITTGF GKFARTVIPA 180
NKLQELQVNL VRSHSSGVGK PLSPERCRML LALRINVLAK GYSGISLETL KQVIEAFNAS 240
CLSYVPEKGT VGASGDLAPL SHLALGLIGE GKMWSPKSGW ADAKYVLEAH GLKPIVLKPK 300
EGLALINGTQ MITSLGCEAL ERASAIARQA DIVAALTLEV LKGTTKAFDT DIHAVRPHRG 360
QIEVAFRFRS LLDSDHHPSE IAESHRFCDR VQDAYTLRCC PQVHGVVNDT IAFVKDIITT 420
ELNSATDNPM VFASRGETIS GGNFHGEYPA KALDYLAIGV HELAAISERR IERLCNPSLS 480
ELPAFLVAEG GLNSGFMIAH CTAAALVSES KALCHPSSVD SLSTSAATED HVSMGGWAAR 540
KALRVVEHVE QVLAIELLAA CQGIEFLRPL KTTTPLEKVY DLVRSVVRPW IKDRFMAPDI 600
EAAHRLLLDQ KVWEVAAPYI EKYRMEHIPE SRPLSPTAFS LESLRKNSAT IPESDDL 657 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0004397; F:histidine ammonia-lyase activity; IDA:MGI.
 GO:0009058; P:biosynthetic process; IEA:InterPro.
 GO:0006548; P:histidine catabolic process; IDA:MGI.
 GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
 GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway. 
Interpro
 IPR001106; Aromatic_Lyase.
 IPR024083; Fumarase/histidase_N.
 IPR005921; HutH.
 IPR008948; L-Aspartase-like.
 IPR022313; Phe/His_NH3-lyase_AS. 
Pfam
 PF00221; Lyase_aromatic 
SMART
  
PROSITE
 PS00488; PAL_HISTIDASE 
PRINTS