CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018391
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fructose-1,6-bisphosphatase class 1 
Protein Synonyms/Alias
 FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 
Gene Name
 fbp 
Gene Synonyms/Alias
 STM4415 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
78EKLKAALKARDIVAGacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
  
Sequence Annotation
 REGION 113 116 Substrate binding (By similarity).
 REGION 257 259 Substrate binding (By similarity).
 METAL 89 89 Magnesium 1 (By similarity).
 METAL 110 110 Magnesium 1 (By similarity).
 METAL 110 110 Magnesium 2 (By similarity).
 METAL 112 112 Magnesium 1; via carbonyl oxygen (By
 METAL 113 113 Magnesium 2 (By similarity).
 METAL 275 275 Magnesium 2 (By similarity).
 BINDING 206 206 Substrate (By similarity).
 BINDING 239 239 Substrate (By similarity).
 BINDING 269 269 Substrate (By similarity).  
Keyword
 Carbohydrate metabolism; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Metal-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 332 AA 
Protein Sequence
MKTLGEFIVE KQHEFSQATG ELTALLSAIK LGAKIIHRDI NKAGLVDILG ASGAENVQGE 60
VQQKLDLFAN EKLKAALKAR DIVAGIASEE EDEIVVFEGC EHAKYVVLMD PLDGSSNIDV 120
NVSVGTIFSI YRRVTPVGTP VTEEDFLQPG NKQVAAGYVV YGSSTMLVYT TGCGVHAFTY 180
DPSLGVFCLC QERMRFPEKG KTYSINEGNY IKFPNGVKKY IKFCQEEDSS TSRPYTSRYI 240
GSLVADFHRN LLKGGIYLYP STASHPQGKL RLLYECNPMA FLAEQAGGKA SDGKERILDI 300
IPESLHQRRS FFVGNRHMVD DVERFIREYP DA 332 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:HAMAP.
 GO:0000287; F:magnesium ion binding; IEA:HAMAP.
 GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
 GO:0019253; P:reductive pentose-phosphate cycle; IEA:HAMAP. 
Interpro
 IPR000146; FBPase_class-1/SBPase.
 IPR020548; Fructose_bisphosphatase_AS. 
Pfam
 PF00316; FBPase 
SMART
  
PROSITE
 PS00124; FBPASE 
PRINTS
 PR00115; F16BPHPHTASE.