UniProt Accession

 H7C0S8_HUMAN; H7C0S8 

Genbank Protein ID

 AC068533 

Genbank Nucleotide ID

  

Protein Name

 Uncharacterized protein 

Protein Synonyms/Alias

  

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
92	GLPSTYNKDLQEDKE	ubiquitination	[1]
211	TDLKEQRKESGKNKH	ubiquitination	[2]
257	REFLTALKSHKLTKA	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 293 AA 

Protein Sequence

Gene Ontology

 GO:0004056; F:argininosuccinate lyase activity; IEA:InterPro.
 GO:0003899; F:DNA-directed RNA polymerase activity; IEA:InterPro.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:InterPro. 

Interpro

 IPR009049; Argininosuccinate_lyase.
 IPR003031; D_crystallin.
 IPR000362; Fumarate_lyase.
 IPR020557; Fumarate_lyase_CS.
 IPR022761; Fumarate_lyase_N.
 IPR010997; HRDC-like.
 IPR008948; L-Aspartase-like.
 IPR005574; RNA_pol_II_Rpb4.
 IPR006590; RNA_pol_II_Rpb4_core. 

Pfam

 PF00206; Lyase_1
 PF03874; RNA_pol_Rpb4 

SMART

 SM00657; RPOL4c 

PROSITE

 PS00163; FUMARATE_LYASES 

PRINTS

 PR00145; ARGSUCLYASE.
 PR00149; FUMRATELYASE.