| Tag | Content |
|---|
| CPLM ID | CPLM-023883 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ankyrin repeat and SOCS box protein 3 |
Protein Synonyms/Alias | ASB-3 |
Gene Name | ASB3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 24 | AAREGNVKVLRKLLK | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B. |
Sequence Annotation | REPEAT 9 38 ANK 1.
REPEAT 42 71 ANK 2.
REPEAT 78 107 ANK 3.
REPEAT 111 140 ANK 4.
REPEAT 145 174 ANK 5.
REPEAT 178 207 ANK 6.
REPEAT 211 240 ANK 7.
REPEAT 246 275 ANK 8.
REPEAT 279 308 ANK 9.
REPEAT 315 346 ANK 10.
REPEAT 348 373 ANK 11.
DOMAIN 441 504 SOCS box. |
Keyword | Alternative splicing; ANK repeat; Complete proteome; Reference proteome; Repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 518 AA |
Protein Sequence | MDFTEAYADT CSTVGLAARE GNVKVLRKLL KKGRSVDVAD NRGWMPIHEA AYHNSVECLQ 60
MLINADSSEN YIKMKTFEGF CALHLAASQG HWKIVQILLE AGADPNATTL EETTPLFLAV 120
ENGQIDVLRL LLQHGANVNG SHSMCGWNSL HQASFQENAE IIKLLLRKGA NKECQDDFGI 180
TPLFVAAQYG KLESLSILIS SGANVNCQAL DKATPLFIAA QEGHTKCVEL LLSSGADPDL 240
YCNEDSWQLP IHAAAQMGHT KILDLLIPLT NRACDTGLNK VSPVYSAVFG GHEDCLEILL 300
RNGYSPDAQA CLVFGFSSPV CMAFQKDCEF FGIVNILLKY GAQINELHLA YCLKYEKFSI 360
FRYFLRKGCS LGPWNHIYEF VNHAIKAQAK YKEWLPHLLV AGFDPLILLC NSWIDSVSID 420
TLIFTLEFTN WKTLAPAVER MLSARASNAW ILQQHIATVP SLTHLCRLEI RSSLKSERLR 480
SDSYISQLPL PRSLHNYLLY EDVLRMYEVP ELAAIQDG 518 |
Gene Ontology | GO:0035556; P:intracellular signal transduction; IEA:InterPro. GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |