| Tag | Content |
|---|
| CPLM ID | CPLM-010651 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Chemokine-like receptor 1 |
Protein Synonyms/Alias | G-protein coupled receptor DEZ |
Gene Name | Cmklr1 |
Gene Synonyms/Alias | Dez; Gpcr27 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 360 | KMSSLNEKASVNEKE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B (By similarity). |
Sequence Annotation | MOD_RES 337 337 Phosphoserine.
MOD_RES 340 340 Phosphothreonine.
MOD_RES 347 347 Phosphoserine.
CARBOHYD 7 7 N-linked (GlcNAc...) (Potential).
CARBOHYD 190 190 N-linked (GlcNAc...) (Potential).
DISULFID 110 187 Potential. |
Keyword | Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 371 AA |
Protein Sequence | MEYDAYNDSG IYDDEYSDGF GYFVDLEEAS PWEAKVAPVF LVVIYSLVCF LGLLGNGLVI 60
VIATFKMKKT VNTVWFVNLA VADFLFNIFL PMHITYAAMD YHWVFGKAMC KISNFLLSHN 120
MYTSVFLLTV ISFDRCISVL LPVWSQNHRS IRLAYMTCSA VWVLAFFLSS PSLVFRDTAN 180
IHGKITCFNN FSLAAPESSP HPAHSQVVST GYSRHVAVTV TRFLCGFLIP VFIITACYLT 240
IVFKLQRNRL AKNKKPFKII ITIIITFFLC WCPYHTLYLL ELHHTAVPSS VFSLGLPLAT 300
AVAIANSCMN PILYVFMGHD FRKFKVALFS RLANALSEDT GPSSYPSHRS FTKMSSLNEK 360
ASVNEKETST L 371 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0004950; F:chemokine receptor activity; IEA:InterPro. GO:0070098; P:chemokine-mediated signaling pathway; IEA:GOC. GO:0006935; P:chemotaxis; IEA:Compara. GO:0032695; P:negative regulation of interleukin-12 production; IMP:UniProtKB. GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB. GO:0010759; P:positive regulation of macrophage chemotaxis; IEA:Compara. GO:0050848; P:regulation of calcium-mediated signaling; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |