| Tag | Content |
|---|
| CPLM ID | CPLM-017904 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ataxin-2 homolog |
Protein Synonyms/Alias | Datx2 |
Gene Name | Atx2 |
Gene Synonyms/Alias | CG5166 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 864 | HVLNPSAKPFTPRGP | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Regulator of actin filament formation, though it does not directly assemble with actin filaments. Required for oocyte specification and oocyte positioning in the female germline. Also required for normal eye development and bristle morphology. |
Sequence Annotation | MOD_RES 208 208 Phosphoserine.
MOD_RES 211 211 Phosphoserine.
MOD_RES 221 221 Phosphoserine.
MOD_RES 266 266 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Phosphoprotein; Reference proteome; RNA editing. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1084 AA |
Protein Sequence | MNNNSKRKTR PTGGGASGGI SRYNSNDNSL RPTNNKAGAG GGNGGAAVRP SAQGVYNNTF 60
FMHSATALVG SVVEVRLRSG NIYEGVFRTF SGNFDIALEL PACIKSKNLP EEGKVPKHII 120
FPADTVVTIV AKDFDSQYAT AGAFQTDGAI SDKCNGARPD EKELEPWDSG ANGDIDIELD 180
SAANGWDPNE MFRKNENTFG VTSTFDDSLA SYTVPLDKGD SLEFKEAEAK AEKLAAEIEN 240
NPTCRDRLDL ENGDEEALFA AVERPSTEQD QRGDRGDRER NDRDREREER DRDRDRDRGN 300
KPRGAGDFQL RETMSSDRYI TKQTRSITGP QLSHVGMSSQ GSGRDRDTRG DGSMMMQSGG 360
GSGQGGSTQS TAALMLAGGL KGVGPAPSAN ASADSSSKYS GGSMVKRKTV PQGGKVMRNN 420
VPTGGSNVSV SQGGNGNSVG QNKGGYQPSM GMPSQYSYQG NSQIMHGSSQ YRNQSHMGGA 480
NKLNGDSNAN TNKPLPQRQM RQYQGSQSNS SLNYGGEPQS LGKPVHGSHG GHPGQNSNSP 540
PLQTAGPQQQ QQQQQQQQQQ QQQQQPPQQQ QHQNIQPQGQ NTQPARQVRT RDNQMQELRQ 600
FGQDFQLAPS NTSPPQQQQQ QQQQQQQHQV QQQQQRALQQ SASPPQQQQQ QQQQQQHVVL 660
HQVPQTHLHQ AALSQPHYVP QQQPQQAPLP QQQHVPHHMQ QKAQQQQLVE TQHQHVQKQH 720
QSQPQVQQPP PQLLQDPSQQ PLPIYHTMPP PQTSPVVVTS PVLLEQPPPQ PMPVVQQQQT 780
QQLATPKPEV SPAPPSSNTT TPTGIASTPT AGVIASAGSE KTTPAAPTPT SNSATVPTGT 840
AATAGGATGT TPVVKKHVLN PSAKPFTPRG PSTPNPSRPH TPQTPVPMTN IYTTTGGHVP 900
PAANQPIYVM QPQHPFPPQT HPQAGQPPRL RRSNYPPMAA SQMHVSASAA TGQPLITAGP 960
IPQFIQYGHA PHQQQFQSHT YAPMQMRVYP DQPQQLQFMT QTPQSTTPSP GQPHQQFHPP 1020
PQPSPAGGGP QPAFTPPTQA ATYQLMCVHP QSLLANHYFP PPTPQHPQQN QQQYQIVMQQ 1080
HQPQ 1084 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:UniProtKB. GO:0022416; P:chaeta development; IMP:UniProtKB. GO:0042051; P:compound eye photoreceptor development; IMP:FlyBase. GO:0009994; P:oocyte differentiation; IMP:UniProtKB. GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase. GO:1901216; P:positive regulation of neuron death; IMP:FlyBase. GO:0030833; P:regulation of actin filament polymerization; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |