CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019572
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Exportin-6 
Protein Synonyms/Alias
 Exp6; Ran-binding protein 20 
Gene Name
 XPO6 
Gene Synonyms/Alias
 KIAA0370; RANBP20 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
288GCDIRARKMASVNGSubiquitination[1]
357DNNAHTVKSRLEELDubiquitination[2]
370LDESYIEKFTDFLRLubiquitination[2]
717SALRLVDKAQVLVCRubiquitination[1]
766SRDYRNLKPSAVAPQubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Mediates the nuclear export of actin and profilin-actin complexes in somatic cells. 
Sequence Annotation
 DOMAIN 31 97 Importin N-terminal.
 MOD_RES 201 201 Phosphothreonine.
 MOD_RES 204 204 Phosphothreonine.
 MOD_RES 224 224 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1125 AA 
Protein Sequence
MASEEASLRA LESLMTEFFH DCTTNERKRE IEELLNNFAQ QIGAWRFCLY FLSSTRNDYV 60
MMYSLTVFEN LINKMWLGVP SQDKMEIRSC LPKLLLAHHK TLPYFIRNKL CKVIVDIGRQ 120
DWPMFYHDFF TNILQLIQSP VTTPLGLIML KTTSEELACP REDLSVARKE ELRKLLLDQV 180
QTVLGLLTGI LETVWDKHSV TAATPPPSPT SGESGDLLSN LLQSPSSAKL LNQPIPILDV 240
ESEYICSLAL ECLAHLFSWI PLSASITPSL LTTIFHFARF GCDIRARKMA SVNGSSQNCV 300
SGQERGRLGV LAMSCINELM SKNCVPMEFE EYLLRMFQQT FYLLQKITKD NNAHTVKSRL 360
EELDESYIEK FTDFLRLFVS VHLRRIESYS QFPVVEFLTL LFKYTFHQPT HEGYFSCLDI 420
WTLFLDYLTS KIKSRLGDKE AVLNRYEDAL VLLLTEVLNR IQFRYNQAQL EELDDETLDD 480
DQQTEWQRYL RQSLEVVAKV MELLPTHAFS TLFPVLQDNL EVYLGLQQFI VTSGSGHRLN 540
ITAENDCRRL HCSLRDLSSL LQAVGRLAEY FIGDVFAARF NDALTVVERL VKVTLYGSQI 600
KLYNIETAVP SVLKPDLIDV HAQSLAALQA YSHWLAQYCS EVHRQNTQQF VTLISTTMDA 660
ITPLISTKVQ DKLLLSACHL LVSLATTVRP VFLISIPAVQ KVFNRITDAS ALRLVDKAQV 720
LVCRALSNIL LLPWPNLPEN EQQWPVRSIN HASLISALSR DYRNLKPSAV APQRKMPLDD 780
TKLIIHQTLS VLEDIVENIS GESTKSRQIC YQSLQESVQV SLALFPAFIH QSDVTDEMLS 840
FFLTLFRGLR VQMGVPFTEQ IIQTFLNMFT REQLAESILH EGSTGCRVVE KFLKILQVVV 900
QEPGQVFKPF LPSIIALCME QVYPIIAERP SPDVKAELFE LLFRTLHHNW RYFFKSTVLA 960
SVQRGIAEEQ MENEPQFSAI MQAFGQSFLQ PDIHLFKQNL FYLETLNTKQ KLYHKKIFRT 1020
AMLFQFVNVL LQVLVHKSHD LLQEEIGIAI YNMASVDFDG FFAAFLPEFL TSCDGVDANQ 1080
KSVLGRNFKM DRDLPSFTQN VHRLVNDLRY YRLCNDSLPP GTVKL 1125 
Gene Ontology
 GO:0005737; C:cytoplasm; IC:UniProtKB.
 GO:0005643; C:nuclear pore; IEA:InterPro.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0008565; F:protein transporter activity; IDA:UniProtKB.
 GO:0006611; P:protein export from nucleus; IDA:UniProtKB. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR013598; Exportin-1/Importin-b-like.
 IPR001494; Importin-beta_N. 
Pfam
 PF03810; IBN_N
 PF08389; Xpo1 
SMART
 SM00913; IBN_N 
PROSITE
 PS50166; IMPORTIN_B_NT 
PRINTS