UniProt Accession

 ITA6_HUMAN; P23229; B2RMU9; B4DG69; B4DKB8; C4AM96; G5E9H1; Q08443; Q0MRC7; Q14646; Q16508; Q53RX7; Q59HB7; Q86VL6; Q9UCT1; Q9UN03 

Genbank Protein ID

 X53586; AF166343; AF166335; AF166336; AF166337; AF166338; AF166339; AF166340; AF166341; AF166342; AK294436; AK296496; AC078883; CH471058; CH471058; BC050585; BC136455; BC136456; X59512; S66213; S66196; S52135; L40385; AB208842; DQ858220 

Genbank Nucleotide ID

 CAA37655.1; AAD48469.1; AAD48469.1; AAD48469.1; AAD48469.1; AAD48469.1; AAD48469.1; AAD48469.1; AAD48469.1; AAD48469.1; BAG57680.1; BAG59130.1; AAX93133.1; EAX11176.1; EAX11177.1; AAH50585.1; AAI36456.1; AAI36457.1; CAA42099.1; AAB20355.1; AAB20354.1; AAB24829.1; BAD92079.1; ABH11650.1 

Protein Name

 Integrin alpha-6 

Protein Synonyms/Alias

 CD49 antigen-like family member F; VLA-6; CD49f; Integrin alpha-6 heavy chain; Integrin alpha-6 light chain 

Gene Name

 ITGA6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
110	ADPTSESKEDQWMGV	ubiquitination	[1]
184	GRLRGHEKFGSCQQG	ubiquitination	[2]
310	SGKGIVSKDEITFVS	ubiquitination	[1, 2]
459	SANGINTKPTQVLKG	ubiquitination	[2]
525	NRIDLRQKTACGAPS	ubiquitination	[2]
690	TREGNQDKFSYLPIQ	ubiquitination	[2]
698	FSYLPIQKGVPELVL	ubiquitination	[1, 2, 3]
902	PKEISNGKWLLYLVK	ubiquitination	[2]
939	TESHNSRKKREITEK	ubiquitination	[1, 3]
986	PLRGLDSKASLILRS	ubiquitination	[2]
1122	EKKQWITKWNENESY	ubiquitination	[4]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. 

Sequence Annotation

 REPEAT 30 95 FG-GAP 1.
 REPEAT 101 166 FG-GAP 2.
 REPEAT 176 229 FG-GAP 3.
 REPEAT 283 340 FG-GAP 4.
 REPEAT 341 402 FG-GAP 5.
 REPEAT 403 458 FG-GAP 6.
 REPEAT 459 518 FG-GAP 7.
 REGION 1077 1083 Interaction with HPS5.
 MOTIF 1079 1083 GFFKR motif.
 CARBOHYD 78 78 N-linked (GlcNAc...) (Potential).
 CARBOHYD 223 223 N-linked (GlcNAc...) (Potential).
 CARBOHYD 323 323 N-linked (GlcNAc...).
 CARBOHYD 409 409 N-linked (GlcNAc...) (Potential).
 CARBOHYD 770 770 N-linked (GlcNAc...) (Potential).
 CARBOHYD 787 787 N-linked (GlcNAc...) (Potential).
 CARBOHYD 930 930 N-linked (GlcNAc...) (Potential).
 CARBOHYD 966 966 N-linked (GlcNAc...) (Potential).
 CARBOHYD 997 997 N-linked (GlcNAc...).
 DISULFID 86 94 By similarity.
 DISULFID 131 154 By similarity.
 DISULFID 175 188 By similarity.
 DISULFID 528 535 By similarity.
 DISULFID 541 601 By similarity.
 DISULFID 665 671 By similarity.
 DISULFID 765 776 By similarity.
 DISULFID 920 967 Interchain (between heavy and light
 DISULFID 973 978 By similarity.  

Keyword

 Alternative splicing; Calcium; Cell adhesion; Cell membrane; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disulfide bond; Epidermolysis bullosa; Glycoprotein; Integrin; Membrane; Metal-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1130 AA 

Protein Sequence

Gene Ontology

 GO:0008305; C:integrin complex; IEA:InterPro.
 GO:0005886; C:plasma membrane; IDA:BHF-UCL.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0030198; P:extracellular matrix organization; TAS:Reactome.
 GO:0031581; P:hemidesmosome assembly; TAS:Reactome.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0043066; P:negative regulation of apoptotic process; IMP:BHF-UCL.
 GO:0043065; P:positive regulation of apoptotic process; IGI:MGI.
 GO:0042327; P:positive regulation of phosphorylation; IMP:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL. 

Interpro

 IPR013519; Int_alpha_beta-p.
 IPR000413; Integrin_alpha.
 IPR013649; Integrin_alpha-2.
 IPR018184; Integrin_alpha_C_CS. 

Pfam

 PF08441; Integrin_alpha2 

SMART

 SM00191; Int_alpha 

PROSITE

 PS51470; FG_GAP
 PS00242; INTEGRIN_ALPHA 

PRINTS

 PR01185; INTEGRINA.