UniProt Accession

 ELP6_MOUSE; Q8BK75; Q9D0M9 

Genbank Protein ID

 AK011270; AK075986; BC048732 

Genbank Nucleotide ID

 BAB27508.1; BAC36098.1; AAH48732.1 

Protein Name

 Elongator complex protein 6 

Protein Synonyms/Alias

 Protein TMEM103 

Gene Name

 Elp6 

Gene Synonyms/Alias

 Tmem103 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
248	QSLTYQYKIQDKNVS	acetylation	[1]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 266 AA 

Protein Sequence

Gene Ontology

 GO:0033588; C:Elongator holoenzyme complex; ISS:UniProtKB.
 GO:0030335; P:positive regulation of cell migration; IMP:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR018627; UPF0405. 

Pfam

 PF09807; DUF2348 

SMART

  

PROSITE

  

PRINTS