| Tag | Content |
|---|
| CPLM ID | CPLM-016249 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tax1-binding protein 1 |
Protein Synonyms/Alias | TRAF6-binding protein |
Gene Name | TAX1BP1 |
Gene Synonyms/Alias | T6BP; PRO0105 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 230 | RFSDATSKAHQLEED | ubiquitination | [1] | | 244 | DIVSVTHKAIEKETE | ubiquitination | [1] | | 465 | RLQKQINKLSDQSAN | ubiquitination | [1] | | 549 | KQLLQDEKAKCNKYA | ubiquitination | [1] | | 577 | VKIAENVKLELAEVQ | ubiquitination | [1] | | 588 | AEVQDNYKELKRSLE | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. |
Sequence Annotation | REGION 320 420 Oligomerization.
MOD_RES 225 225 Phosphoserine.
MOD_RES 593 593 Phosphoserine; by IKKA.
MOD_RES 666 666 Phosphoserine; by IKKA. |
Keyword | Alternative splicing; Apoptosis; Coiled coil; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 789 AA |
Protein Sequence | MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV GIFKVGWSTA 60
RDYYTFLWSP MPEHYVEGST VNCVLAFQGY YLPNDDGEFY QFCYVTHKGE IRGASTPFQF 120
RASSPVEELL TMEDEGNSDM LVVTTKAGLL ELKIEKTMKE KEELLKLIAV LEKETAQLRE 180
QVGRMERELN HEKERCDQLQ AEQKGLTEVT QSLKMENEEF KKRFSDATSK AHQLEEDIVS 240
VTHKAIEKET ELDSLKDKLK KAQHEREQLE CQLKTEKDEK ELYKVHLKNT EIENTKLMSE 300
VQTLKNLDGN KESVITHFKE EIGRLQLCLA EKENLQRTFL LTTSSKEDTC FLKEQLRKAE 360
EQVQATRQEV VFLAKELSDA VNVRDRTMAD LHTARLENEK VKKQLADAVA ELKLNAMKKD 420
QDKTDTLEHE LRREVEDLKL RLQMAADHYK EKFKECQRLQ KQINKLSDQS ANNNNVFTKK 480
TGNQQKVNDA SVNTDPATSA STVDVKPSPS AAEADFDIVT KGQVCEMTKE IADKTEKYNK 540
CKQLLQDEKA KCNKYADELA KMELKWKEQV KIAENVKLEL AEVQDNYKEL KRSLENPAER 600
KMEDGADGAF YPDEIQRPPV RVPSWGLEDN VVCSQPARNF SRPDGLEDSE DSKEDENVPT 660
APDPPSQHLR GHGTGFCFDS SFDVHKKCPL CELMFPPNYD QSKFEEHVES HWKVCPMCSE 720
QFPPDYDQQV FERHVQTHFD QNVLNFD 747 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0019900; F:kinase binding; ISS:BHF-UCL. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0045087; P:innate immune response; TAS:Reactome. GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc. GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:BHF-UCL. GO:0032480; P:negative regulation of type I interferon production; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
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PRINTS | |