UniProt Accession

 PON1_RAT; P55159; O08682; Q5BJN6 

Genbank Protein ID

 CH473959; BC091403; U94856 

Genbank Nucleotide ID

 EDM15017.1; AAH91403.1; AAB53441.1 

Protein Name

 Serum paraoxonase/arylesterase 1 

Protein Synonyms/Alias

 PON 1; Aromatic esterase 1; A-esterase 1; Serum aryldialkylphosphatase 1 

Gene Name

 Pon1 

Gene Synonyms/Alias

 Pon 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
340	VAAVYKGKLLIGTVF	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification (By similarity). 

Sequence Annotation

 ACT_SITE 115 115 Proton acceptor (By similarity).
 METAL 53 53 Calcium 1; catalytic (By similarity).
 METAL 54 54 Calcium 2 (By similarity).
 METAL 117 117 Calcium 2; via carbonyl oxygen (By
 METAL 168 168 Calcium 1; catalytic (By similarity).
 METAL 169 169 Calcium 2 (By similarity).
 METAL 224 224 Calcium 1; catalytic (By similarity).
 METAL 269 269 Calcium 1; catalytic (By similarity).
 METAL 270 270 Calcium 1; catalytic (By similarity).
 CARBOHYD 253 253 N-linked (GlcNAc...) (Potential).
 CARBOHYD 270 270 N-linked (GlcNAc...) (Potential).
 CARBOHYD 324 324 N-linked (GlcNAc...) (Potential).
 DISULFID 42 353 By similarity.  

Keyword

 Calcium; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; HDL; Hydrolase; Metal-binding; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 355 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IDA:RGD.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD.
 GO:0034366; C:spherical high-density lipoprotein particle; IEA:Compara.
 GO:0004063; F:aryldialkylphosphatase activity; ISS:UniProtKB.
 GO:0004064; F:arylesterase activity; ISS:UniProtKB.
 GO:0005509; F:calcium ion binding; ISS:UniProtKB.
 GO:0005543; F:phospholipid binding; IEA:Compara.
 GO:0019439; P:aromatic compound catabolic process; IEA:Compara.
 GO:0046395; P:carboxylic acid catabolic process; IEA:Compara.
 GO:0006629; P:lipid metabolic process; IEP:RGD.
 GO:0046434; P:organophosphate catabolic process; IEA:Compara.
 GO:0046470; P:phosphatidylcholine metabolic process; IEA:Compara.
 GO:0051099; P:positive regulation of binding; IEA:Compara.
 GO:0010875; P:positive regulation of cholesterol efflux; IEA:Compara.
 GO:0032411; P:positive regulation of transporter activity; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:Compara. 

Interpro

 IPR011042; 6-blade_b-propeller_TolB-like.
 IPR002640; Arylesterase.
 IPR008363; Paraoxonase1. 

Pfam

 PF01731; Arylesterase 

SMART

  

PROSITE

  

PRINTS

 PR01785; PARAOXONASE.
 PR01786; PARAOXONASE1.