CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044525
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Abhydrolase domain-containing protein 3 
Protein Synonyms/Alias
  
Gene Name
 ABHD3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
93KHRHMFVKQVDMDHVubiquitination[1, 2, 3, 4, 5]
137ASPSPRLKSVGIPVLubiquitination[2, 3, 4]
200TYMDRVFKQFVQAMVubiquitination[4, 5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 214 AA 
Protein Sequence
MTFITPVTEI ITYCSLQLQW PSKLFFPRML LLNYLGKIGS KTPLMAAATF SVGWNTFACS 60
ESLEKPLNWL LFNYYLTTCL QSSVNKHRHM FVKQVDMDHV MKAKSIREFD KRFTSVMFGY 120
QTIDDYYTDA SPSPRLKSVG IPVLCLNSVD DVFSPSHAIP IETAKQNPNV ALVLTSYGGH 180
IGFLEGIWPR QSTYMDRVFK QFVQAMVEHG HELS 214 
Gene Ontology
 GO:0004091; F:carboxylesterase activity; IEA:InterPro. 
Interpro
 IPR012020; AB-Hydro_YheT.
 IPR000952; UPF0017_hydro-like_CS. 
Pfam
  
SMART
  
PROSITE
 PS01133; UPF0017 
PRINTS