CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012819
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Poly [ADP-ribose] polymerase 14 
Protein Synonyms/Alias
 PARP-14; ADP-ribosyltransferase diphtheria toxin-like 8; ARTD8; Collaborator of STAT6; CoaSt6 
Gene Name
 Parp14 
Gene Synonyms/Alias
 Kiaa1268 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
976YLVGLPAKVARAFAEubiquitination[1]
1121AWSLKIMKNIIRDCLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Has ADP-ribosyltransferase activity (By similarity). Enhances STAT6-dependent transcription. 
Sequence Annotation
 DOMAIN 802 989 Macro 1.
 DOMAIN 1014 1202 Macro 2.
 DOMAIN 1227 1398 Macro 3.
 DOMAIN 1539 1617 WWE.
 DOMAIN 1621 1817 PARP catalytic.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Glycosyltransferase; NAD; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1817 AA 
Protein Sequence
MAASGSFPLL VEGSWGPDPP KNLINKLQVY FQSRKKSGGG ECEVVPEPGN PARFRVLFSP 60
EDVRQNVLER GNHELVWQEK GTFKLTVLMP TDPEEASASK KSRKESPEEE SKTKEDAVKQ 120
GDLDITHSPS SGSEKTEDVP KECENISSMV AFENLPEKVS EMVLTILVEN ISGLPSDDFK 180
VEVNRDFAVA VVTFQKPIDI KKFIVDCISH RSNQQLQLAP RLLETTNVVR VENLPPGVDE 240
YQLQLFFENP FNGGGRVARV ECFPEESSAL VEFCDSKVLD TVMAKTHSYN KMPLSVFPYY 300
PSLGTALYGE EKPLIKLPAS FQESLDLPLW KFFQKNNHLI EEINNEMRCC HCELTWSEIN 360
GKLTIRPAAT LVNHRLSIKT WQRDASAVLS GIKSKYGVEL FEVCSPVWDI IKHELESGDD 420
RVLVEFEKES LNIAGKSEDV QGMSQKIREL IESTTEKLRR EEQSLKEKVA ISPGKHYLLH 480
HSGFLKDLSK GFPEMEISYD ATAQFLYLKG FRADVYKVKC DIQEKVFSMA QKDVQVSSEV 540
FEFLQQVDSQ RLSKSLFEAQ NILAIYELKG TALFLVGSSF KDLAEAETKM LSALSHKQIE 600
VEDKEVLISN GWKKKVHPLQ KRHSSCATII VQNELTSETP AKVIVTGCVK EVNEIHRQLF 660
EYLENNMKVE RALKIKPSLI VDYLRTDKRL LSKIKKAHVY VHFKPKDNPN SILLTGCKSK 720
VLECMNLVKE IQDSVCVQRF QTDKAGVRHF FKDKESYYKT EIGRQFGCVI ELEEDREEKG 780
EEEDGEEEEG EEEGESSINE QKCHLQRDIA PGVKLFVLEE DLSRFPVDVV VNAANENLKH 840
ISGLAQALSK AAGPELQTEC DQIVKEGGVV LPGNAVISKA GKLPCHHVIH AVGPRWKGDK 900
VLECVSLLKK VVRQSLSLAE EHRCRSIAMP AVSAGIFDFP LELCVANIVS AIKEHFQHKR 960
DTHTLKKIYL VGLPAKVARA FAEAVKTTYK DSLSHTAFPS SLKALVPLGK TPQKQGSLLV 1020
SPEGLRIRLV EEGVQNATTH AIVNSISPDL KLNKGPLSQA FLEKAGPKLQ EELTRSGQGV 1080
SVDVGTILQT SGCNLNSRHV FHVVPPPWKS NNSAWSLKIM KNIIRDCLKT TENLSLQSIA 1140
FPAIGTGNLR FPKPEFAKLI ISEVLKFSSR NQLKTLQEVQ FLLHPKDHEN IQAFSDEFDK 1200
RNNGDPSDKN PKAEDTQGIY GSLSSPTLGM HEMNIGPILF QVATGNIIKE VADVIVNSTT 1260
LTFDLKSGVS KAILEGAGQN VEQECSLLAK QSNHGYIVTG GGLLQCKNII HVVGGNDVKK 1320
SVSCVLEECE QRNYSSICLP AIGTGNAQQD PNVVAKAIID AIEEFVQKKS VQAVKRVKVV 1380
IFQPHILQFF YDNMKEREGS PAPPKQSPAK QSVMSKIASF LGFPKQASPK KNTLVLEKKI 1440
EHTVFQVCGS GVDSVNKTIS WLKELITKEQ LSYTNDDECV SDFDMEEYEK LNEIQKELNI 1500
TIEMNQKKTS IQVSGISRDV IKARDEIEGM IKSIRLAKEK ESQADYISTY VEWQYIDKNI 1560
TQCFDKMTNM KLEVAWKAKK KDTVVQIHNQ DFTVDLSTNT ATAPQGQTFT VQRLVKAEAE 1620
IPANWSDMKQ DKLLLVNLQT SDPEYNMVAS AFRQTCSNFF IEKIERIQNP ALWRRYQAYK 1680
KSMDEKNGNV RNEKHLFHGT EASSLPQLNS NGFNRSYAGK NATAYGKGTY FAVKASYSAC 1740
DTYSRPDTNG RKYMYYVRVL TGNYTNGNAS LIVPPSRDPQ NAADLYDTVT DNDKNPSIFV 1800
VFYDNQTYPE YLITFRQ 1817 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:EC.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR002589; A1pp.
 IPR012317; Poly(ADP-ribose)pol_cat_dom.
 IPR000504; RRM_dom.
 IPR004170; WWE-dom. 
Pfam
 PF01661; Macro
 PF00644; PARP 
SMART
 SM00506; A1pp
 SM00360; RRM 
PROSITE
 PS51154; MACRO
 PS51059; PARP_CATALYTIC
 PS50918; WWE 
PRINTS