UniProt Accession

 DC1L1_HUMAN; Q9Y6G9; A2RRG7; Q53HC8; Q53HK7 

Genbank Protein ID

 AF078849; AK222573; AK222653; CH471055; BC131620 

Genbank Nucleotide ID

 AAD44481.1; BAD96293.1; BAD96373.1; EAW64433.1; AAI31621.1 

Protein Name

 Cytoplasmic dynein 1 light intermediate chain 1 

Protein Synonyms/Alias

 LIC1; Dynein light chain A; DLC-A; Dynein light intermediate chain 1, cytosolic 

Gene Name

 DYNC1LI1 

Gene Synonyms/Alias

 DNCLI1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
310	KLYGFPYKIPAVVVE	ubiquitination	[1]
385	KLQSLLAKQPPTAAG	ubiquitination	[1, 2]
455	FNSLLSKKTGSPGGP	ubiquitination	[2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress throuh the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. 

Sequence Annotation

 NP_BIND 74 81 ATP (Potential).
 MOD_RES 207 207 Phosphoserine.
 MOD_RES 213 213 Phosphothreonine.
 MOD_RES 398 398 Phosphoserine.
 MOD_RES 405 405 Phosphoserine.
 MOD_RES 408 408 Phosphothreonine.
 MOD_RES 419 419 Phosphoserine.
 MOD_RES 421 421 Phosphoserine.
 MOD_RES 487 487 Phosphoserine.
 MOD_RES 510 510 Phosphoserine.
 MOD_RES 512 512 Phosphothreonine.
 MOD_RES 513 513 Phosphothreonine.
 MOD_RES 515 515 Phosphothreonine.
 MOD_RES 516 516 Phosphoserine.
 MOD_RES 518 518 Phosphothreonine (By similarity).  

Keyword

 ATP-binding; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Dynein; Host-virus interaction; Kinetochore; Microtubule; Mitosis; Motor protein; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 523 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005868; C:cytoplasmic dynein complex; IDA:UniProtKB.
 GO:0000776; C:kinetochore; IDA:UniProtKB.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0000922; C:spindle pole; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0090267; P:positive regulation of mitotic cell cycle spindle assembly checkpoint; IMP:UniProtKB.
 GO:0006810; P:transport; IEA:UniProtKB-KW.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR008467; Dynein1_light_intermed_chain.
 IPR022780; Dynein_light_int_chain.
 IPR027417; P-loop_NTPase. 

Pfam

 PF05783; DLIC 

SMART

  

PROSITE

  

PRINTS