UniProt Accession

 TIM21_MOUSE; Q8CCM6; Q8CE44; Q9CYU8; Q9CZS4 

Genbank Protein ID

 AK012203; AK013281; AK029037; AK032468; BC034297 

Genbank Nucleotide ID

 BAB28097.1; BAB28768.1; BAC26258.1; BAC27885.1; AAH34297.1 

Protein Name

 Mitochondrial import inner membrane translocase subunit Tim21 

Protein Synonyms/Alias

 TIM21-like protein, mitochondrial 

Gene Name

 Timm21 

Gene Synonyms/Alias

 Tim21 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
192	GLKRIRVKFYIEGSE	acetylation	[1]

Reference

 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex. TIM21 probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes (By similarity). 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Membrane; Mitochondrion; Protein transport; Reference proteome; Transit peptide; Translocation; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 249 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005744; C:mitochondrial inner membrane presequence translocase complex; ISS:UniProtKB.
 GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
 GO:0033617; P:mitochondrial respiratory chain complex IV assembly; ISS:UniProtKB.
 GO:0030150; P:protein import into mitochondrial matrix; ISS:UniProtKB. 

Interpro

 IPR013261; Tim21. 

Pfam

 PF08294; TIM21 

SMART

  

PROSITE

  

PRINTS