UniProt Accession

 H7BX22_MOUSE; H7BX22 

Genbank Protein ID

 AC084822 

Genbank Nucleotide ID

  

Protein Name

 Ran-specific GTPase-activating protein 

Protein Synonyms/Alias

  

Gene Name

 Ranbp1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
18	ENDLPEWKERGTGDV	ubiquitination	[1]
61	ITPMMELKPNAGSDR	acetylation	[2]
84	DFADECPKPELLAIR	acetylation	[2]
100	LNAENAQKFKTKFEE	acetylation	[2, 3, 4, 5]
100	LNAENAQKFKTKFEE	succinylation	[5]
100	LNAENAQKFKTKFEE	ubiquitination	[1]
104	NAQKFKTKFEECRKE	acetylation	[2]
132	NAEKVAEKLEALSVR	acetylation	[2, 4, 5]
132	NAEKVAEKLEALSVR	succinylation	[5]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 153 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:MGI.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0046907; P:intracellular transport; IEA:InterPro.
 GO:0046604; P:positive regulation of mitotic centrosome separation; IDA:MGI.
 GO:0007051; P:spindle organization; IDA:MGI. 

Interpro

 IPR011993; PH_like_dom.
 IPR000156; Ran_bind_dom. 

Pfam

 PF00638; Ran_BP1 

SMART

 SM00160; RanBD 

PROSITE

 PS50196; RANBD1 

PRINTS