| Tag | Content |
|---|
| CPLM ID | CPLM-005240 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ferrochelatase |
Protein Synonyms/Alias | Heme synthase; Protoheme ferro-lyase |
Gene Name | hemH |
Gene Synonyms/Alias | popA; visA; b0475; JW0464 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 182 | SVRASFAKHGEPDLL | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Catalyzes the ferrous insertion into protoporphyrin IX. |
Sequence Annotation | METAL 194 194 Iron (By similarity).
METAL 275 275 Iron (By similarity). |
Keyword | Complete proteome; Cytoplasm; Direct protein sequencing; Heme biosynthesis; Iron; Lyase; Metal-binding; Porphyrin biosynthesis; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 320 AA |
Protein Sequence | MRQTKTGILL ANLGTPDAPT PEAVKRYLKQ FLSDRRVVDT SRLLWWPLLR GVILPLRSPR 60
VAKLYASVWM EGGSPLMVYS RQQQQALAQR LPEMPVALGM SYGSPSLESA VDELLAEHVD 120
HIVVLPLYPQ FSCSTVGAVW DELARILARK RSIPGISFIR DYADNHDYIN ALANSVRASF 180
AKHGEPDLLL LSYHGIPQRY ADEGDDYPQR CRTTTRELAS ALGMAPEKVM MTFQSRFGRE 240
PWLMPYTDET LKMLGEKGVG HIQVMCPGFA ADCLETLEEI AEQNREVFLG AGGKKYEYIP 300
ALNATPEHIE MMANLVAAYR 320 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0004325; F:ferrochelatase activity; IDA:EcoCyc. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0006783; P:heme biosynthetic process; IDA:EcoliWiki. GO:0046501; P:protoporphyrinogen IX metabolic process; IMP:EcoliWiki. GO:0009416; P:response to light stimulus; IMP:EcoliWiki. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |