UniProt Accession

 ACE_HUMAN; P12821; B0LPF0; B4DXI3; E7EU16; P22966; Q53YX9; Q59GY8; Q7M4L4 

Genbank Protein ID

 J04144; M26657; X16295; AF118569; AY436326; AK301988; EU332840; AB208971; AC113554 

Genbank Nucleotide ID

 AAA51684.1; AAA60611.1; CAA34362.1; AAD28560.1; AAR03504.1; BAG63395.1; ABY87529.1; BAD92208.1 

Protein Name

 Angiotensin-converting enzyme 

Protein Synonyms/Alias

 ACE; Dipeptidyl carboxypeptidase I; Kininase II; CD143; Angiotensin-converting enzyme, soluble form 

Gene Name

 ACE 

Gene Synonyms/Alias

 DCP; DCP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
718	QLQNTTIKRIIKKVQ	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. 

Sequence Annotation

 REGION 30 630 Peptidase M2 1.
 REGION 631 1232 Peptidase M2 2.
 ACT_SITE 391 391 1.
 ACT_SITE 989 989 2.
 METAL 390 390 Zinc 1; catalytic.
 METAL 394 394 Zinc 1; catalytic.
 METAL 418 418 Zinc 1; catalytic.
 METAL 988 988 Zinc 2; catalytic.
 METAL 992 992 Zinc 2; catalytic.
 METAL 1016 1016 Zinc 2; catalytic.
 BINDING 231 231 Chloride 1.
 BINDING 529 529 Chloride 1.
 BINDING 791 791 Chloride 2.
 BINDING 829 829 Chloride 3.
 BINDING 1090 1090 Chloride 2.
 BINDING 1094 1094 Chloride 2.
 BINDING 1127 1127 Chloride 3.
 MOD_RES 1299 1299 Phosphoserine.
 CARBOHYD 38 38 N-linked (GlcNAc...) (Probable).
 CARBOHYD 54 54 N-linked (GlcNAc...).
 CARBOHYD 74 74 N-linked (GlcNAc...).
 CARBOHYD 111 111 N-linked (GlcNAc...).
 CARBOHYD 146 146 N-linked (GlcNAc...).
 CARBOHYD 160 160 N-linked (GlcNAc...) (Potential).
 CARBOHYD 318 318 N-linked (GlcNAc...).
 CARBOHYD 445 445 N-linked (GlcNAc...).
 CARBOHYD 509 509 N-linked (GlcNAc...).
 CARBOHYD 677 677 N-linked (GlcNAc...) (Potential).
 CARBOHYD 695 695 N-linked (GlcNAc...) (complex).
 CARBOHYD 714 714 N-linked (GlcNAc...) (complex).
 CARBOHYD 760 760 N-linked (GlcNAc...); partial.
 CARBOHYD 942 942 N-linked (GlcNAc...); partial.
 CARBOHYD 1191 1191 N-linked (GlcNAc...); partial.
 DISULFID 157 165
 DISULFID 757 763
 DISULFID 957 975
 DISULFID 1143 1155  

Keyword

 3D-structure; Alternative splicing; Carboxypeptidase; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Hydrolase; Membrane; Metal-binding; Metalloprotease; Phosphoprotein; Polymorphism; Protease; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1306 AA 

Protein Sequence

Gene Ontology

 GO:0005768; C:endosome; IDA:BHF-UCL.
 GO:0009897; C:external side of plasma membrane; IDA:BHF-UCL.
 GO:0005615; C:extracellular space; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0003779; F:actin binding; IDA:UniProtKB.
 GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
 GO:0031404; F:chloride ion binding; IDA:BHF-UCL.
 GO:0008144; F:drug binding; IDA:BHF-UCL.
 GO:0004175; F:endopeptidase activity; IDA:UniProtKB.
 GO:0008237; F:metallopeptidase activity; IDA:UniProtKB.
 GO:0008241; F:peptidyl-dipeptidase activity; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IDA:BHF-UCL.
 GO:0002005; P:angiotensin catabolic process in blood; IC:UniProtKB.
 GO:0002003; P:angiotensin maturation; TAS:Reactome.
 GO:0050482; P:arachidonic acid secretion; IDA:BHF-UCL.
 GO:0001974; P:blood vessel remodeling; IC:BHF-UCL.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0060218; P:hematopoietic stem cell differentiation; IC:BHF-UCL.
 GO:0042447; P:hormone catabolic process; IDA:BHF-UCL.
 GO:0001822; P:kidney development; IMP:BHF-UCL.
 GO:0032943; P:mononuclear cell proliferation; IC:BHF-UCL.
 GO:0043171; P:peptide catabolic process; IDA:BHF-UCL.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0002019; P:regulation of renal output by angiotensin; IC:BHF-UCL.
 GO:0014910; P:regulation of smooth muscle cell migration; ISS:BHF-UCL.
 GO:0019229; P:regulation of vasoconstriction; IC:UniProtKB.
 GO:0042312; P:regulation of vasodilation; IC:BHF-UCL. 

Interpro

 IPR001548; Peptidase_M2. 

Pfam

 PF01401; Peptidase_M2 

SMART

  

PROSITE

 PS00142; ZINC_PROTEASE 

PRINTS

 PR00791; PEPDIPTASEA.