CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011087
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Secretogranin-2 
Protein Synonyms/Alias
 Chromogranin-C; Secretogranin II; SgII; Secretoneurin; SN 
Gene Name
 Scg2 
Gene Synonyms/Alias
 Chgc; Scg-2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
311QLSEDASKVITYLRRacetylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Secretogranin-2 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. 
Sequence Annotation
 MOD_RES 153 153 Sulfotyrosine (By similarity).  
Keyword
 Calcium; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Reference proteome; Secreted; Signal; Sulfation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 617 AA 
Protein Sequence
MAGAKAYRLG AVLLLIHLIF LISGAEAASF QRNQLLQKEP DLRLENVQKF PSPEMIRALE 60
YIEKLRQQAH REESSPDYNP YQGVSVPLQL KENGEESHLA ESSRDALSED EWMRIILEAL 120
RQAENEPPSA PKENKPYALN LEKNFPVDTP DDYETQQWPE RKLKHMRFPL MYEENSRENP 180
FKRTNEIVEE QYTPQSLATL ESVFQELGKL TGPSNQKRER VDEEQKLYTD DEDDVYKTNN 240
IAYEDVVGGE DWSPIEEKIE TQTQEEVRDS KENTEKNEQI NEEMKRSGQL GLPDEENRRE 300
SKDQLSEDAS KVITYLRRLV NAVGSGRSQS GPNGDRAARL LQKPLDSQSI YQLIEISRNL 360
QIPPEDLIEM LKAGEKPNGL VEPEQDLELA VDLDDIPEAD LDRPDMFQSK MLSKGGYPKA 420
PGRGMVEALP DGLSVEDILN VLGMENVVNQ KSPYFPNQYS QDKALMRLPY GPGKSRANQI 480
PKVAWIPDVE SRQAPYENLN DQELGEYLAR MLVKYPELLN TNQLKRVPSP VSSEDDLQEE 540
EQLEQAIKEH LGPGSSQEME RLAKVSKRIP VGSLKNEDTP NRQYLDEDML LKVLEYLNQE 600
QAEQGREHLA KRAMENM 617 
Gene Ontology
 GO:0005615; C:extracellular space; ISS:HGNC.
 GO:0030141; C:secretory granule; IEA:InterPro.
 GO:0042056; F:chemoattractant activity; ISS:HGNC.
 GO:0005125; F:cytokine activity; ISS:HGNC.
 GO:0001525; P:angiogenesis; IDA:HGNC.
 GO:0048245; P:eosinophil chemotaxis; ISS:HGNC.
 GO:0050930; P:induction of positive chemotaxis; ISS:HGNC.
 GO:0000165; P:MAPK cascade; ISS:HGNC.
 GO:0043066; P:negative regulation of apoptotic process; ISS:HGNC.
 GO:0001938; P:positive regulation of endothelial cell proliferation; ISS:HGNC. 
Interpro
 IPR001990; Granin. 
Pfam
 PF01271; Granin 
SMART
  
PROSITE
 PS00422; GRANINS_1 
PRINTS