UniProt Accession

 F7BX26_MOUSE; F7BX26 

Genbank Protein ID

 AC148976 

Genbank Nucleotide ID

  

Protein Name

 Serine/threonine-protein phosphatase 

Protein Synonyms/Alias

  

Gene Name

 Ppp5c 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
39	TQANDYFKAKDYENA	acetylation	[1]
110	ASNMALGKFRAALRD	acetylation	[1]
129	VKVKPNDKDAKMKYQ	acetylation	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

  

Sequence Annotation

 ACT_SITE 281 281 Proton donor (By similarity).
 METAL 219 219 Iron (By similarity).
 METAL 221 221 Iron (By similarity).
 METAL 248 248 Iron (By similarity).  

Keyword

 Complete proteome; Hydrolase; Iron; Metal-binding; Reference proteome; Repeat; TPR repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 476 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004721; F:phosphoprotein phosphatase activity; IMP:MGI.
 GO:0006470; P:protein dephosphorylation; IEA:InterPro.
 GO:0043278; P:response to morphine; IMP:MGI. 

Interpro

 IPR004843; Metallo_PEstase_dom.
 IPR013235; PPP_dom.
 IPR006186; Ser/Thr-sp_prot-phosphatase.
 IPR011236; Ser/Thr_PPase_5.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 

Pfam

 PF00149; Metallophos
 PF08321; PPP5
 PF00515; TPR_1 

SMART

 SM00156; PP2Ac
 SM00028; TPR 

PROSITE

 PS00125; SER_THR_PHOSPHATASE
 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS

 PR00114; STPHPHTASE.