UniProt Accession

 RCAN1_HUMAN; P53805; D3DSF9; O00582; O00583; Q53XT0; Q6IBC6; Q7Z555; Q96R03; Q9BU69; Q9UF15; Q9UME4 

Genbank Protein ID

 U28833; U85265; U85266; U85267; AY325903; AF400429; AK092184; CR456878; AP000326; AP000327; CH471079; CH471079; U53821; BC002864; BT007363 

Genbank Nucleotide ID

 AAB81557.1; AAB84370.1; AAB84371.2; AAB84372.1; AAP96743.1; AAK92478.1; BAG52494.1; CAG33159.1; EAX09779.1; EAX09782.1; AAF21218.1; AAH02864.1; AAP36027.1 

Protein Name

 Calcipressin-1 

Protein Synonyms/Alias

 Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1 

Gene Name

 RCAN1 

Gene Synonyms/Alias

 ADAPT78; CSP1; DSC1; DSCR1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
86	VDGLCRAKFESLFRT	ubiquitination	[1]
134	HKTEFLGKEMKLYFA	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 252 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0008015; P:blood circulation; TAS:ProtInc.
 GO:0019722; P:calcium-mediated signaling; IEA:InterPro.
 GO:0007417; P:central nervous system development; TAS:ProtInc.
 GO:0051151; P:negative regulation of smooth muscle cell differentiation; IEA:Compara.
 GO:0043666; P:regulation of phosphoprotein phosphatase activity; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0009612; P:response to mechanical stimulus; IEA:Compara.
 GO:0007165; P:signal transduction; TAS:ProtInc.
 GO:0048741; P:skeletal muscle fiber development; IEA:Compara. 

Interpro

 IPR006931; Calcipressin. 

Pfam

 PF04847; Calcipressin 

SMART

  

PROSITE

  

PRINTS