CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035884
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 60 kDa chaperonin 
Protein Synonyms/Alias
 GroEL protein; Protein Cpn60 
Gene Name
 groL 
Gene Synonyms/Alias
 groEL; EAM_0419 
Created Date
 July 27, 2013 
Organism
 Erwinia amylovora (strain ATCC 49946 / CCPPB 0273 / Ea273 / 27-3) 
NCBI Taxa ID
 716540 
Lysine Modification
Position
Peptide
Type
References
132IAAVEELKKLSVPCSacetylation[1]
133AAVEELKKLSVPCSDacetylation[1]
207LSPYFINKPETGAVEacetylation[1]
225PFILLADKKISNIREacetylation[1]
226FILLADKKISNIRELacetylation[1]
364TSDYDREKLQERVAKacetylation[1]
Reference
 [1] Differential lysine acetylation profiles of Erwinia amylovora strains revealed by proteomics.
 Wu X, Vellaichamy A, Wang D, Zamdborg L, Kelleher NL, Huber SC, Zhao Y.
 J Proteomics. 2013 Feb 21;79:60-71. [PMID: 23234799] 
Functional Description
 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity). 
Sequence Annotation
  
Keyword
 ATP-binding; Chaperone; Complete proteome; Cytoplasm; Nucleotide-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 548 AA 
Protein Sequence
MAAKDVKFGN DARVKMLRGV NVLADAVKVT LGPKGRNVVL DKSFGSPTIT KDGVSVAREI 60
ELEDKFENMG AQMVKEVASK ANDAAGDGTT TATVLAQSIV NEGLKAVAAG MNPMDLKRGI 120
DKAVIAAVEE LKKLSVPCSD SKAIAQVGTI SANSDETVGE LIAQAMEKVG KEGVITVEEG 180
TGLQDELDVV EGMQFDRGYL SPYFINKPET GAVELESPFI LLADKKISNI RELLPVLEAV 240
AKAGKPLLII AEDVEGEALA TLVVNTMRGI VKVAAVKAPG FGDRRKAMLQ DIAVLTGGTV 300
ISEEIGMELE KAALEDMGQA KRVVINKDTT TIIDGTGEEV AISGRVTQIR QQIEEATSDY 360
DREKLQERVA KLAGGVAVLK VGAATEVEMK EKKARVEDAL HATRAAVEEG VVAGGGVALV 420
RVAAVLADLR GQNEDQNVGI KVALRAMESP LRQIVSNAGE EPSVVTNAVK AGEGNYGYNA 480
QTEEYGNMID FGILDPTKVT RSALQYAASV AGLMITTECM VTDLPKGDAP DLGAGGGMGG 540
MGGMGGMM 548 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0042026; P:protein refolding; IEA:HAMAP. 
Interpro
 IPR018370; Chaperonin_Cpn60_CS.
 IPR001844; Chaprnin_Cpn60.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00296; CHAPERONINS_CPN60 
PRINTS
 PR00298; CHAPERONIN60.