CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020094
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ADP-dependent glucokinase 
Protein Synonyms/Alias
 ADP-GK; ADPGK; RbBP-35 
Gene Name
 ADPGK 
Gene Synonyms/Alias
 PSEC0260 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
104GLSPGNGKDHSILHSubiquitination[1]
125AFIHFMGKGAAAERFubiquitination[1, 2]
450RIVLNPNKPVVEWHRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity). 
Sequence Annotation
 DOMAIN 52 497 ADPK.
 ACT_SITE 481 481 Proton acceptor (By similarity).
 METAL 297 297 Magnesium (By similarity).
 METAL 328 328 Magnesium (By similarity).
 METAL 481 481 Magnesium (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Glycolysis; Kinase; Magnesium; Metal-binding; Polymorphism; Reference proteome; Secreted; Signal; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 497 AA 
Protein Sequence
MALWRGSAYA GFLALAVGCV FLLEPELPGS ALRSLWSSLC LGPAPAPPGP VSPEGRLAAA 60
WDALIVRPVR RWRRVAVGVN ACVDVVLSGV KLLQALGLSP GNGKDHSILH SRNDLEEAFI 120
HFMGKGAAAE RFFSDKETFH DIAQVASEFP GAQHYVGGNA ALIGQKFAAN SDLKVLLCGP 180
VGPKLHELLD DNVFVPPESL QEVDEFHLIL EYQAGEEWGQ LKAPHANRFI FSHDLSNGAM 240
NMLEVFVSSL EEFQPDLVVL SGLHMMEGQS KELQRKRLLE VVTSISDIPT GIPVHLELAS 300
MTNRELMSSI VHQQVFPAVT SLGLNEQELL FLTQSASGPH SSLSSWNGVP DVGMVSDILF 360
WILKEHGRSK SRASDLTRIH FHTLVYHILA TVDGHWANQL AAVAAGARVA GTQACATETI 420
DTSRVSLRAP QEFMTSHSEA GSRIVLNPNK PVVEWHREGI SFHFTPVLVC KDPIRTVGLG 480
DAISAEGLFY SEVHPHY 497 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0043843; F:ADP-specific glucokinase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway. 
Interpro
 IPR007666; ADP_PFK/GK. 
Pfam
 PF04587; ADP_PFK_GK 
SMART
  
PROSITE
 PS51255; ADPK 
PRINTS