| Tag | Content |
|---|
| CPLM ID | CPLM-002521 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Thymidine phosphorylase |
Protein Synonyms/Alias | TdRPase |
Gene Name | deoA |
Gene Synonyms/Alias | tpp; ttg; b4382; JW4345 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 73 | SGTVLDWKSLHLNGP | acetylation | [1] | | 147 | NRFREIIKDVGVAII | acetylation | [1] | | 165 | SSLAPADKRFYATRD | acetylation | [1] | | 190 | ITASILAKKLAEGLD | acetylation | [1] | | 291 | LISGKLAKDDAEARA | acetylation | [1] | | 299 | DDAEARAKLQAVLDN | acetylation | [1] | | 308 | QAVLDNGKAAEVFGR | acetylation | [1] | | 332 | DFVENYAKYLPTAML | acetylation | [1] | | 405 | PLAVIHAKDENNWQE | acetylation | [1] | | 415 | NNWQEAAKAVKAAIK | acetylation | [1] | | 426 | AAIKLADKAPESTPT | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. |
Sequence Annotation | |
Keyword | 3D-structure; Complete proteome; Glycosyltransferase; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 440 AA |
Protein Sequence | MFLAQEIIRK KRDGHALSDE EIRFFINGIR DNTISEGQIA ALAMTIFFHD MTMPERVSLT 60
MAMRDSGTVL DWKSLHLNGP IVDKHSTGGV GDVTSLMLGP MVAACGGYIP MISGRGLGHT 120
GGTLDKLESI PGFDIFPDDN RFREIIKDVG VAIIGQTSSL APADKRFYAT RDITATVDSI 180
PLITASILAK KLAEGLDALV MDVKVGSGAF MPTYELSEAL AEAIVGVANG AGVRTTALLT 240
DMNQVLASSA GNAVEVREAV QFLTGEYRNP RLFDVTMALC VEMLISGKLA KDDAEARAKL 300
QAVLDNGKAA EVFGRMVAAQ KGPTDFVENY AKYLPTAMLT KAVYADTEGF VSEMDTRALG 360
MAVVAMGGGR RQASDTIDYS VGFTDMARLG DQVDGQRPLA VIHAKDENNW QEAAKAVKAA 420
IKLADKAPES TPTVYRRISE 440 |
Gene Ontology | GO:0016020; C:membrane; IDA:UniProtKB. GO:0004645; F:phosphorylase activity; IEA:InterPro. GO:0016154; F:pyrimidine-nucleoside phosphorylase activity; IEA:InterPro. GO:0009032; F:thymidine phosphorylase activity; IEA:EC. GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:InterPro. GO:0006213; P:pyrimidine nucleoside metabolic process; IEA:InterPro. GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |