UniProt Accession

 TRIP6_HUMAN; Q15654; A4D2E7; F2ZC07; F2ZC08; O15170; O15275; Q9BTB2; Q9BUE5; Q9BXP3; Q9UNT4 

Genbank Protein ID

 AJ001902; AF000974; AF093836; AF093834; AF093835; AF312032; AB628086; AB628087; AK291906; AC011895; CH236956; CH471091; BC002680; BC004249; BC004999; BC021540; BC028985; L40374 

Genbank Nucleotide ID

 CAA05080.1; AAB62222.1; AAD03037.1; AAD03037.1; AAD03037.1; AAK21007.1; BAK20497.1; BAK20498.1; BAF84595.1; EAL23817.1; EAW76472.1; AAH02680.1; AAH04249.1; AAH04999.1; AAH21540.1; AAH28985.1; AAC41740.1 

Protein Name

 Thyroid receptor-interacting protein 6 

Protein Synonyms/Alias

 TR-interacting protein 6; TRIP-6; Opa-interacting protein 1; OIP-1; Zyxin-related protein 1; ZRP-1 

Gene Name

 TRIP6 

Gene Synonyms/Alias

 OIP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
458	LDGHILCKACSAWRI	ubiquitination	[1]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. 

Sequence Annotation

 DOMAIN 279 316 LIM zinc-binding 1.
 DOMAIN 339 398 LIM zinc-binding 2.
 DOMAIN 399 467 LIM zinc-binding 3.
 REGION 469 476 Interaction with MAGI1 and PTPN13.
 MOD_RES 55 55 Phosphotyrosine; by SRC.
 MOD_RES 92 92 Phosphoserine.
 MOD_RES 142 142 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; Cell adhesion; Cell junction; Complete proteome; Cytoplasm; Cytoskeleton; LIM domain; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 476 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005925; C:focal adhesion; IDA:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005149; F:interleukin-1 receptor binding; IDA:UniProtKB.
 GO:0046966; F:thyroid hormone receptor binding; NAS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0048041; P:focal adhesion assembly; NAS:UniProtKB.
 GO:0030335; P:positive regulation of cell migration; IMP:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0008588; P:release of cytoplasmic sequestered NF-kappaB; IDA:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR001781; Znf_LIM. 

Pfam

 PF00412; LIM 

SMART

 SM00132; LIM 

PROSITE

 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 

PRINTS