CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009950
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ancient ubiquitous protein 1 
Protein Synonyms/Alias
  
Gene Name
 Aup1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
143VELVESLKKFCASTRubiquitination[1]
144ELVESLKKFCASTRLubiquitination[1]
250RVQQLVAKELGQIGTubiquitination[1]
264TRLTPADKAEHMKRQubiquitination[1]
269ADKAEHMKRQRHPRLubiquitination[1]
305TTLAHRVKEVLPHVPubiquitination[1]
377PTALTFAKSSWARQEubiquitination[1]
390QESLQERKQALYEYAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (By similarity). 
Sequence Annotation
 DOMAIN 296 338 CUE.
 MOD_RES 292 292 Phosphoserine (By similarity).
 MOD_RES 363 363 Phosphoserine (By similarity).
 MOD_RES 367 367 Phosphothreonine (By similarity).  
Keyword
 Complete proteome; Endoplasmic reticulum; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 410 AA 
Protein Sequence
MEPPPAPGPE RLFDSHRLPS DGFLLLALLL YAPVGLCLLV LRLFLGLHVF LVSCALPDSV 60
LRRFVVRTMC AVLGLVARQE DSGLRDHRVR VLISNHVTPF DHNIVNLLTT CSTPLLNSPP 120
SFVCWSRGFM EMDRRVELVE SLKKFCASTR LPPTPLLLFP EEEATNGREG LLRFSSWPFS 180
IQDVVQPLTL QVQRPLVSVT VSDASWVSEL LWSLFVPFTV YQVRWLHPIR RQLGEESEEF 240
ALRVQQLVAK ELGQIGTRLT PADKAEHMKR QRHPRLRPQS VQSSFPSPPS PSSDVQLTTL 300
AHRVKEVLPH VPLNVIQRDL ARTGCVDLTI TNLLEGAVAF MPEDVTEGSQ SPPAPSAPKF 360
PSSGLATPQP TALTFAKSSW ARQESLQERK QALYEYARRR FRERQAQEAE 410 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0016746; F:transferase activity, transferring acyl groups; IEA:InterPro. 
Interpro
 IPR003892; CUE.
 IPR002123; Plipid/glycerol_acylTrfase. 
Pfam
 PF02845; CUE 
SMART
 SM00546; CUE
 SM00563; PlsC 
PROSITE
 PS51140; CUE 
PRINTS