CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002395
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Receptor-type tyrosine-protein phosphatase C 
Protein Synonyms/Alias
 Leukocyte common antigen; L-CA; Lymphocyte antigen 5; Ly-5; T200; CD45 
Gene Name
 Ptprc 
Gene Synonyms/Alias
 Ly-5 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
704ASYIDGFKEPRKYIAubiquitination[1]
774VVTINDHKRCPDYIIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity. 
Sequence Annotation
 DOMAIN 371 467 Fibronectin type-III 1.
 DOMAIN 472 559 Fibronectin type-III 2.
 DOMAIN 640 899 Tyrosine-protein phosphatase 1.
 DOMAIN 931 1214 Tyrosine-protein phosphatase 2.
 REGION 840 846 Substrate binding (By similarity).
 ACT_SITE 840 840 Phosphocysteine intermediate (By
 ACT_SITE 1155 1155 Phosphocysteine intermediate (By
 BINDING 808 808 Substrate (By similarity).
 BINDING 884 884 Substrate (By similarity).
 MOD_RES 940 940 Phosphoserine.
 MOD_RES 962 962 Phosphoserine.
 MOD_RES 1284 1284 Phosphoserine (By similarity).
 CARBOHYD 64 64 N-linked (GlcNAc...) (Potential).
 CARBOHYD 150 150 N-linked (GlcNAc...) (Potential).
 CARBOHYD 161 161 N-linked (GlcNAc...) (Potential).
 CARBOHYD 207 207 N-linked (GlcNAc...) (Potential).
 CARBOHYD 211 211 N-linked (GlcNAc...) (Potential).
 CARBOHYD 218 218 N-linked (GlcNAc...) (Potential).
 CARBOHYD 253 253 N-linked (GlcNAc...) (Potential).
 CARBOHYD 258 258 N-linked (GlcNAc...) (Potential).
 CARBOHYD 290 290 N-linked (GlcNAc...) (Potential).
 CARBOHYD 311 311 N-linked (GlcNAc...) (Potential).
 CARBOHYD 322 322 N-linked (GlcNAc...) (Potential).
 CARBOHYD 347 347 N-linked (GlcNAc...) (Potential).
 CARBOHYD 416 416 N-linked (GlcNAc...) (Potential).
 CARBOHYD 427 427 N-linked (GlcNAc...) (Potential).
 CARBOHYD 457 457 N-linked (GlcNAc...) (Potential).
 CARBOHYD 489 489 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Direct protein sequencing; Glycoprotein; Hydrolase; Membrane; Phosphoprotein; Protein phosphatase; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1291 AA 
Protein Sequence
MGLWLKLLAF GFALLDTEVF VTGQTPTPSD ELSTTENALL LPQSDPLPAR TTESTPPSIS 60
ERGNGSSETT YHPGVLSTLL PHLSPQPDSQ TPSAGGADTQ TFSSQADNPT LTPAPGGGTD 120
PPGVPGERTV PGTIPADTAF PVDTPSLARN SSAASPTHTS NVSTTDISSG ASLTTLTPST 180
LGLASTDPPS TTIATTTKQT CAAMFGNITV NYTYESSNQT FKADLKDVQN AKCGNEDCEN 240
VLNNLEECSQ IKNISVSNDS CAPATTIDLY VPPGTDKFSL HDCTPKEKAN TSICLEWKTK 300
NLDFRKCNSD NISYVLHCEP ENNTKCIRRN TFIPERCQLD NLRAQTNYTC VAEILYRGVK 360
LVKNVINVQT DLGIPETPKP SCGDPAARKT LVSWPEPVSK PESASKPHGY VLCYKNNSEK 420
CKSLPNNVTS FEVESLKPYK YYEVSLLAYV NGKIQRNGTA EKCNFHTKAD RPDKVNGMKT 480
SRPTDNSINV TCGPPYETNG PKTFYILVVR SGGSFVTKYN KTNCQFYVDN LYYSTDYEFL 540
VSFHNGVYEG DSVIRNESTN FNAKALIIFL VFLIIVTSIA LLVVLYKIYD LRKKRSSNLD 600
EQQELVERDD EKQLMDVEPI HSDILLETYK RKIADEGRLF LAEFQSIPRV FSKFPIKDAR 660
KPHNQNKNRY VDILPYDYNR VELSEINGDA GSTYINASYI DGFKEPRKYI AAQGPRDETV 720
DDFWRMIWEQ KATVIVMVTR CEEGNRNKCA EYWPSMEEGT RAFKDIVVTI NDHKRCPDYI 780
IQKLNVAHKK EKATGREVTH IQFTSWPDHG VPEDPHLLLK LRRRVNAFSN FFSGPIVVHC 840
SAGVGRTGTY IGIDAMLEGL EAEGKVDVYG YVVKLRRQRC LMVQVEAQYI LIHQALVEYN 900
QFGETEVNLS ELHSCLHNMK KRDPPSDPSP LEAEYQRLPS YRSWRTQHIG NQEENKKKNR 960
NSNVVPYDFN RVPLKHELEM SKESEPESDE SSDDDSDSEE TSKYINASFV MSYWKPEMMI 1020
AAQGPLKETI GDFWQMIFQR KVKVIVMLTE LVNGDQEVCA QYWGEGKQTY GDMEVEMKDT 1080
NRASAYTLRT FELRHSKRKE PRTVYQYQCT TWKGEELPAE PKDLVSMIQD LKQKLPKASP 1140
EGMKYHKHAS ILVHCRDGSQ QTGLFCALFN LLESAETEDV VDVFQVVKSL RKARPGVVCS 1200
YEQYQFLYDI IASIYPAQNG QVKKTNSQDK IEFHNEVDGG KQDANCVRPD GPLNKAQEDS 1260
RGVGTPEPTN SAEEPEHAAN GSASPAPTQS S 1291 
Gene Ontology
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0005925; C:focal adhesion; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; ISS:UniProtKB.
 GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
 GO:0043395; F:heparan sulfate proteoglycan binding; IDA:MGI.
 GO:0008201; F:heparin binding; IDA:MGI.
 GO:0019901; F:protein kinase binding; ISS:UniProtKB.
 GO:0004725; F:protein tyrosine phosphatase activity; ISS:UniProtKB.
 GO:0000187; P:activation of MAPK activity; IMP:MGI.
 GO:0030183; P:B cell differentiation; IMP:MGI.
 GO:0042100; P:B cell proliferation; IMP:UniProtKB.
 GO:0050853; P:B cell receptor signaling pathway; IMP:UniProtKB.
 GO:0048539; P:bone marrow development; IEA:Compara.
 GO:0051607; P:defense response to virus; IMP:UniProtKB.
 GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Compara.
 GO:0034113; P:heterotypic cell-cell adhesion; IMP:MGI.
 GO:0002378; P:immunoglobulin biosynthetic process; IEA:Compara.
 GO:0007159; P:leukocyte cell-cell adhesion; IMP:MGI.
 GO:0006933; P:negative regulation of cell adhesion involved in substrate-bound cell migration; IEA:Compara.
 GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IDA:UniProtKB.
 GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; IMP:MGI.
 GO:0031953; P:negative regulation of protein autophosphorylation; IMP:MGI.
 GO:0006469; P:negative regulation of protein kinase activity; IDA:UniProtKB.
 GO:0001915; P:negative regulation of T cell mediated cytotoxicity; IMP:UniProtKB.
 GO:0045060; P:negative thymic T cell selection; IMP:MGI.
 GO:0046641; P:positive regulation of alpha-beta T cell proliferation; IMP:MGI.
 GO:0050857; P:positive regulation of antigen receptor-mediated signaling pathway; IMP:UniProtKB.
 GO:0043065; P:positive regulation of apoptotic process; IMP:MGI.
 GO:0030890; P:positive regulation of B cell proliferation; IMP:MGI.
 GO:0045588; P:positive regulation of gamma-delta T cell differentiation; IMP:MGI.
 GO:2000473; P:positive regulation of hematopoietic stem cell migration; IEA:Compara.
 GO:0002925; P:positive regulation of humoral immune response mediated by circulating immunoglobulin; IMP:MGI.
 GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IMP:MGI.
 GO:2000648; P:positive regulation of stem cell proliferation; IEA:Compara.
 GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IMP:MGI.
 GO:0045059; P:positive thymic T cell selection; IMP:MGI.
 GO:0045577; P:regulation of B cell differentiation; IMP:MGI.
 GO:0050855; P:regulation of B cell receptor signaling pathway; IMP:MGI.
 GO:0051726; P:regulation of cell cycle; IDA:UniProtKB.
 GO:0033261; P:regulation of S phase; IEA:Compara.
 GO:0051209; P:release of sequestered calcium ion into cytosol; IDA:UniProtKB.
 GO:0010332; P:response to gamma radiation; IEA:Compara.
 GO:0048864; P:stem cell development; IEA:Compara.
 GO:0042098; P:T cell proliferation; IMP:MGI.
 GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR013783; Ig-like_fold.
 IPR016335; Leukocyte_common_ag.
 IPR024739; PTP_recept_N.
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS.
 IPR000242; Tyr_Pase_rcpt/non-rcpt. 
Pfam
 PF12567; CD45
 PF12453; PTP_N
 PF00102; Y_phosphatase 
SMART
 SM00060; FN3
 SM00194; PTPc 
PROSITE
 PS50853; FN3
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50055; TYR_PHOSPHATASE_PTP 
PRINTS
 PR00700; PRTYPHPHTASE.