CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012942
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-rich repeat-containing protein 8E 
Protein Synonyms/Alias
  
Gene Name
 Lrrc8e 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
630LSFQHCRKLVILRLWubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
 REPEAT 535 556 LRR 1.
 REPEAT 558 578 LRR 2.
 REPEAT 582 603 LRR 3.
 REPEAT 605 626 LRR 4.
 REPEAT 630 651 LRR 5.
 REPEAT 653 674 LRR 6.
 REPEAT 676 697 LRR 7.
 REPEAT 699 720 LRR 8.
 REPEAT 722 743 LRR 9.
 REPEAT 745 766 LRR 10.
 CARBOHYD 63 63 N-linked (GlcNAc...) (Potential).
 CARBOHYD 301 301 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Leucine-rich repeat; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 795 AA 
Protein Sequence
MIPVAEFKQF TEQQPAFKVL KPWWDVLAEY LTVAMLMIGV FGCTLQVTQD KIICLPSHES 60
RENSSEAPCQ QLLPQGISEQ IGGLRELSGL KNNLDLQQYS FINQLCYETA LHWYAKYFPY 120
LVVIHTLIFM VCTSFWFKFP GTSSKIEHFI SILGKCFDSP WTTRALSEVS GENHKGPAAG 180
RATVTTVTTV GTGTGKVGEG EKEKVLIEPE KVVTEPPAVT LLDKKEGEQA KALFEKVKKF 240
RVHVEEGDIL YSMYIRQTVL KVCKFFAILV YNLVYVEKIS FLVACRVETS EITGYASFCC 300
NHTKAHLFSK LAFCYISFVC VYGITCLYTL YWLFHRPLKE YSFRSVREET GMNDIPDVRN 360
DFAFMLHLID QYDSLYSKRF AVFLSEVSES RLKQLNLNHE WTPDKLRQKL QRNARGRLEL 420
SLCMLPGLPD TVFELSEVEA LRLEAICDIS FPPGLSQLVN LQELSLLHSP ARLPFSSQIF 480
LRDRLKVICV KFEELREVPL WVFGLRGLEE LHLEGLFPPE MARGATLESL RELKQLKVLS 540
LRSNAGKVPA SVTDVAGHLQ RLSLHNDGAR LLALNSLKKL AVLRELELVA CGLERIPHAI 600
FSLGALQELD LKDNHLRSIE EILSFQHCRK LVILRLWHNQ IAYVPEHVRK LRSLEQLYLS 660
HNKLETLPAQ LGQCFGLRLL DVSHNGLRSL PPELGLLQSL QHLALSYNAL ESLPDELFFC 720
HKLRTLLLGY NHLTQFSPHV AALQALSRLE LKGNRLEALP EELGDCKGLK KSGLLVEDTL 780
YEGLPAEVRE KMEEE 795 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR021040; LRR_protein-8_N. 
Pfam
 PF12534; DUF3733
 PF12799; LRR_4 
SMART
 SM00369; LRR_TYP 
PROSITE
 PS51450; LRR 
PRINTS