UniProt Accession

 NDRG1_HUMAN; Q92597; B3KR80; B7Z446; O15207; Q6IBG2; Q9NYR6; Q9UK29 

Genbank Protein ID

 D87953; X92845; AF004162; AF186190; CR456842; AK091147; AK126924; AK296794; AF192304; CH471060; BC003175; AF230380 

Genbank Nucleotide ID

 BAA13505.1; CAA63430.1; AAC13419.1; CAG33123.1; BAG52292.1; BAG54400.1; BAH12432.1; EAW92164.1; AAH03175.1; AAF71305.1 

Protein Name

 Protein NDRG1 

Protein Synonyms/Alias

 Differentiation-related gene 1 protein; DRG-1; N-myc downstream-regulated gene 1 protein; Nickel-specific induction protein Cap43; Reducing agents and tunicamycin-responsive protein; RTP; Rit42 

Gene Name

 NDRG1 

Gene Synonyms/Alias

 CAP43; DRG1; RTP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
14	DVDLAEVKPLVEKGE	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. 

Sequence Annotation

 REPEAT 339 348 1.
 REPEAT 349 358 2.
 REPEAT 359 368 3.
 REGION 339 368 3 X 10 AA tandem repeats of G-T-R-S-R-S-
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 2 2 Phosphoserine (By similarity).
 MOD_RES 326 326 Phosphoserine.
 MOD_RES 328 328 Phosphothreonine; by SGK1.
 MOD_RES 330 330 Phosphoserine; by SGK1.
 MOD_RES 332 332 Phosphoserine; by SGK1.
 MOD_RES 333 333 Phosphoserine.
 MOD_RES 335 335 Phosphothreonine (By similarity).
 MOD_RES 336 336 Phosphoserine.
 MOD_RES 346 346 Phosphothreonine; by SGK1.
 MOD_RES 356 356 Phosphothreonine; by SGK1.
 MOD_RES 362 362 Phosphoserine (By similarity).
 MOD_RES 364 364 Phosphoserine; by SGK1.
 MOD_RES 366 366 Phosphothreonine; by SGK1.
 MOD_RES 375 375 Phosphothreonine.  

Keyword

 Acetylation; Alternative splicing; Cell membrane; Charcot-Marie-Tooth disease; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Microtubule; Neuropathy; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 394 AA 

Protein Sequence

Gene Ontology

 GO:0005913; C:cell-cell adherens junction; IDA:UniProtKB.
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0055038; C:recycling endosome membrane; IDA:UniProtKB.
 GO:0045296; F:cadherin binding; IDA:UniProtKB.
 GO:0043015; F:gamma-tubulin binding; IDA:UniProtKB.
 GO:0008017; F:microtubule binding; IDA:UniProtKB.
 GO:0017137; F:Rab GTPase binding; IDA:UniProtKB.
 GO:0071456; P:cellular response to hypoxia; IEP:UniProtKB.
 GO:0030330; P:DNA damage response, signal transduction by p53 class mediator; IEP:UniProtKB.
 GO:0045576; P:mast cell activation; IEA:Compara.
 GO:0032287; P:peripheral nervous system myelin maintenance; IEA:Compara.
 GO:0090232; P:positive regulation of spindle checkpoint; IDA:UniProtKB.
 GO:0010038; P:response to metal ion; TAS:ProtInc. 

Interpro

 IPR004142; Ndr. 

Pfam

 PF03096; Ndr 

SMART

  

PROSITE

  

PRINTS