CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011066
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 U4/U6 small nuclear ribonucleoprotein PRP3 
Protein Synonyms/Alias
 Pre-mRNA-splicing factor 3 
Gene Name
 PRP3 
Gene Synonyms/Alias
 RNA3; YDR473C; D8035.16 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
51TELHSALKSSNLNLIacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919
Functional Description
 Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. 
Sequence Annotation
  
Keyword
 Complete proteome; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 469 AA 
Protein Sequence
MPPRNTYEKG NPKRQNSPYY KPSFLRREET TNDEEKFQGH GLKTELHSAL KSSNLNLIRR 60
TYQTGENPYL SDPHDRGSSS RFNRRYERGL KFYQKGEISK RIAQERTLQK QQEEEELKRK 120
LKQEEDEKDK RKLIESGDLP NLELHEDKFL LDLSKFKIYY DNNHGYEWWD TAYLDEKGEL 180
MEKYDMNGTS PAEEKLAEDI DEVDDDDDDE HPSIRYVAHP LPEKINEAKV SIKAYLTQHE 240
RKRLRRNRRK MAREAREIKI KLGLLPKPEP KVKLSNMMSV FENDQNITDP TAWEKVVKDQ 300
VDLRKRKHLE ENERRHEDAI KRRKEAVNMN VEKPTVYHCK VFQFKNLQNP KIRFKLKMNS 360
KELSLKGLCL RIRDDGPGII IVVGNEKSCK FYENLVMKRI KWNEDFELHT NTGDIKMDMH 420
NNSISKTWEG YLQDCKFKGW FMKVCNDQDS LLRTLGQFDS EHFYSPVQT 469 
Gene Ontology
 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IDA:SGD.
 GO:0000398; P:mRNA splicing, via spliceosome; IPI:SGD. 
Interpro
 IPR010541; DUF1115.
 IPR013881; Pre-mRNA_splic_Prp3.
 IPR027104; Prp3. 
Pfam
 PF06544; DUF1115
 PF08572; PRP3 
SMART
  
PROSITE
  
PRINTS