UniProt Accession

 BRE_BOVIN; A6QQW8 

Genbank Protein ID

 BC150022 

Genbank Nucleotide ID

 AAI50023.1 

Protein Name

 BRCA1-A complex subunit BRE 

Protein Synonyms/Alias

 BRCA1/BRCA2-containing complex subunit 45; Brain and reproductive organ-expressed protein 

Gene Name

 BRE 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Bos taurus (Bovine) 

NCBI Taxa ID

 9913 

Lysine Modification

Position	Peptide	Type	References
41	CLRITDLKSGCTSLT	ubiquitination	[1]
382	EAAFANGKL******	ubiquitination	[1]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin (By similarity). 

Sequence Annotation

 REGION 30 147 UEV-like 1.
 REGION 275 364 UEV-like 2.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 Phosphoserine (By similarity).  

Keyword

 Acetylation; Apoptosis; Chromatin regulator; Complete proteome; Cytoplasm; DNA damage; DNA repair; Nucleus; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 383 AA 

Protein Sequence

Gene Ontology

 GO:0070531; C:BRCA1-A complex; ISS:UniProtKB.
 GO:0070552; C:BRISC complex; ISS:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0000152; C:nuclear ubiquitin ligase complex; IEA:Compara.
 GO:0031593; F:polyubiquitin binding; ISS:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0006302; P:double-strand break repair; ISS:UniProtKB.
 GO:0031572; P:G2 DNA damage checkpoint; ISS:UniProtKB.
 GO:0045739; P:positive regulation of DNA repair; ISS:UniProtKB.
 GO:0010212; P:response to ionizing radiation; ISS:UniProtKB. 

Interpro

 IPR010358; Brain/reproduct-express_prot. 

Pfam

 PF06113; BRE 

SMART

  

PROSITE

  

PRINTS