CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023324
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Coproporphyrinogen-III oxidase 
Protein Synonyms/Alias
 COX; Coprogen oxidase; Coproporphyrinogenase 
Gene Name
 Coprox 
Gene Synonyms/Alias
 CG3433 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
341LIYDRGTKFGLYTPGacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity). 
Sequence Annotation
 REGION 131 140 Important for dimerization (By
 REGION 197 199 Substrate binding (By similarity).
 REGION 329 365 Important for dimerization (By
 REGION 348 353 Substrate binding (By similarity).
 ACT_SITE 195 195 Proton donor (By similarity).
 BINDING 181 181 Substrate (By similarity).  
Keyword
 Complete proteome; Heme biosynthesis; Oxidoreductase; Porphyrin biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 390 AA 
Protein Sequence
MNALRHTISL VSLGTFQLVR RTRGPHARGF LLGTGLGLAS FSAVTYAHSA EAVDPKVNGV 60
QMNTSRFMAE PITDSKALLG DKENMRHRME ILIMEIQAEF CRALEAEENC GQKFKVDRWE 120
RPEGGGGITC VLQDGDVFEK AGVNISVVTG SLPPAAVQQM RARGKNLKEG ASLPFFASGV 180
SAVIHPRNPH VPTIHFNYRY FEVETAKGEK QWWFGGGTDL TPYYLCEKDA SHFHQTLKSA 240
CDEHDPTYYP RFKKWCDDYF RIKHRNESRG IGGIFFDDID SPNQEAAFNF VSSCARAVIP 300
SYVPLVRKHK NREYGNNERQ WQLLRRGRYV EFNLIYDRGT KFGLYTPGAR YESILMSLPL 360
HARWEYMHEP KSQSEEGKLM KVLKNPKDWV 390 
Gene Ontology
 GO:0004109; F:coproporphyrinogen oxidase activity; ISS:FlyBase.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR001260; Coprogen_oxidase_aer.
 IPR018375; Coprogen_oxidase_CS. 
Pfam
 PF01218; Coprogen_oxidas 
SMART
  
PROSITE
 PS01021; COPROGEN_OXIDASE 
PRINTS
 PR00073; COPRGNOXDASE.