CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030375
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphodiesterase 6A, cGMP-specific, rod, alpha 
Protein Synonyms/Alias
  
Gene Name
 Pde6a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
326IDYILHGKEDIKVIPubiquitination[1]
613TNNLYQMKSQNPLAKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Hydrolase; Metal-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 860 AA 
Protein Sequence
MGEVTAEEVE KFLDSNIGFA KQYYNLHYRG KVISDLLGAK EAAVDFSNYH DVNSVEESEI 60
IFDLLRDVQE NLQAEKCTFN VMKKLCFLLR ADRMSLFMYR TRNGIAELAT RLFNVHKDAV 120
LEDCLVMPDS EIVFPLDMGV VGHVAHSKKI ANVPNTEEDE HFCDFVDNLT EYQTKNILAS 180
PIMNGKDVVA IIMAVNKIDE PHFTKRDEEI LLKYLNFVNL IMKVFHLSYL HNCETRRGQI 240
LLWSGSKVFE ELTDIERQFH KALYTVRAFL NCDRYSVGLL DMTKQKEFFD VWPVLMGEAP 300
AYSGPRTPDG REINFYKVID YILHGKEDIK VIPNPPADHW ALVSGLPTYV AQNGLICNIM 360
NAPAEDFFEF QKEPLDESGW MIKNVLSMPI VNKKEEIVGV ATFYNRKDGK PFDDMDETLM 420
ESLTQFLGWS VLNPDTYESM NKLENRKDIF QDIVKYHVKC DNEEIQKILK TREVYGKEPW 480
ECEEEELAEI LQGELPDAES YEINKFHFSD LPLTELELVK CGIQMYYELR VVDKFHIPQE 540
ALVRFMYSLS KGYRRITYHN WRHGFNVGQT MFSLLVTGKL KWYFTDLEAL AMVTAAFCHD 600
IDHRGTNNLY QMKSQNPLAK LHGSSILERH HLEFGKTLLR DESLNIFQNL NRRQHEHAIH 660
MMDIAIIATD LALYFKKRTM FQKIVDQSKT YESTQEWTQY MMLEQTRKEI VMAMMMTACD 720
LSAITKPWEV QSKVALLVAA EFWEQGDLER TVLQQNPIPM MDRNKADELP KLQVGFIDFV 780
CTFVYKEFSR FHEEITPMLD GITNNRKEWK ALADEYEAKM KALEEEKQNQ QAAKQAASGN 840
QPGGNPTPGG APASKSCCIQ 860 
Gene Ontology
 GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008152; P:metabolic process; IEA:GOC.
 GO:0060041; P:retina development in camera-type eye; IMP:MGI.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR003018; GAF.
 IPR003607; HD/PDEase_dom.
 IPR023088; PDEase.
 IPR002073; PDEase_catalytic_dom.
 IPR023174; PDEase_CS. 
Pfam
 PF01590; GAF
 PF00233; PDEase_I 
SMART
 SM00065; GAF
 SM00471; HDc 
PROSITE
 PS00126; PDEASE_I 
PRINTS
 PR00387; PDIESTERASE1.