CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032435
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Mitochondrial inner membrane protein 
Protein Synonyms/Alias
  
Gene Name
 IMMT 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
84KTIPYSDKLFEMVLGubiquitination[1]
101AYNVPLPKKSIQSGPubiquitination[2]
102YNVPLPKKSIQSGPLubiquitination[2, 3]
110SIQSGPLKISSVSEVubiquitination[1, 2]
119SSVSEVMKESKQPASubiquitination[3]
164ARLAQQEKQEQVKIEacetylation[4, 5]
222NSEIAGEKKSAQWRTubiquitination[1]
223SEIAGEKKSAQWRTVubiquitination[3]
235RTVEGALKERRKAVDacetylation[5]
235RTVEGALKERRKAVDubiquitination[3]
376NRELAEQKATEKQHIubiquitination[1]
404AFDSAVAKALEHHRSubiquitination[2, 3, 5, 6]
459RVQEQELKSEFEQNLubiquitination[1, 6]
469FEQNLSEKLSEQELQubiquitination[1, 3, 6]
518VAEEEARKAHQLWLSubiquitination[1]
534EALKYSMKTSSAETPubiquitination[1, 3, 6]
593ARFYAVQKLARRVAMubiquitination[1, 2, 3]
667AKFVNQLKGESRRVAubiquitination[1, 3]
679RVAQDWLKEARMTLEubiquitination[1, 3]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 711 AA 
Protein Sequence
MLRACQLSGV TAAAQSCLCG KFVLRPLRPC RRYSTSGSSG LTTGKIAGAG LLFVGGGIGG 60
TILYAKWDSH FRESVEKTIP YSDKLFEMVL GPAAYNVPLP KKSIQSGPLK ISSVSEVMKE 120
SKQPASQLQK QKGDTPASAT EASSSSIRER PPEEVAARLA QQEKQEQVKI ESLAKSLEDA 180
LRQTASVTLQ AIAAQNAAVQ AVNAHSNILK AAMDNSEIAG EKKSAQWRTV EGALKERRKA 240
VDEAADALLK AKEELEKMKS VIENAKKKEV AGAKPHITAA EGKLHNMIVD LDNVVKKVQA 300
AQSEAKVVSQ YHELVVQARD DFKRELDSIT PEVLPGWKGM SVSDLADKLS TDDLNSLIAH 360
AHRRIDQLNR ELAEQKATEK QHITLALEKQ KLEEKRAFDS AVAKALEHHR SEIQAEQDRK 420
IEEVRDAMEN EMRTQLRRQA AAHTDHLRDV LRVQEQELKS EFEQNLSEKL SEQELQFRRL 480
SQEQVDNFTL DINTAYARLR GIEQAVQSHA VAEEEARKAH QLWLSVEALK YSMKTSSAET 540
PTIPLGSAVE AIKANCSDNE FTQALTAAIP PESLTRGVYS EETLRARFYA VQKLARRVAM 600
IDETRNSLYQ YFLSYLQSLL LFPPQQLKPP PELCPEDINT FKLLSYASYC IEHGDLELAA 660
KFVNQLKGES RRVAQDWLKE ARMTLETKQI VEILTAYASA VGIGTTQVQP E 711 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-KW. 
Interpro
 IPR019133; Mt-IM_prot_Mitofilin. 
Pfam
 PF09731; Mitofilin 
SMART
  
PROSITE
  
PRINTS