UniProt Accession

 DLG3_HUMAN; Q92796; B4E0H1; D3DVU5; Q5JUW6; Q5JUW7; Q9ULI8 

Genbank Protein ID

 U49089; AB033058; AK303377; AK304020; AK316518; AL139109; AL139398; AL139398; CH471132; CH471132; CH471132; CH471132; BC093864; BC093866 

Genbank Nucleotide ID

 AAB61453.1; BAA86546.1; BAG64433.1; BAG64935.1; BAH14889.1; CAI41022.1; CAI41023.1; EAX05333.1; EAX05335.1; EAX05337.1; EAX05338.1; AAH93864.1; AAH93866.1 

Protein Name

 Disks large homolog 3 

Protein Synonyms/Alias

 Neuroendocrine-DLG; Synapse-associated protein 102; SAP-102; SAP102; XLMR 

Gene Name

 DLG3 

Gene Synonyms/Alias

 KIAA1232 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
6	**MERARKFSGSGLA	ubiquitination	[1, 2]
276	KFPFYKSKENMAQES	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. 

Sequence Annotation

 DOMAIN 130 217 PDZ 1.
 DOMAIN 226 311 PDZ 2.
 DOMAIN 379 465 PDZ 3.
 DOMAIN 503 568 SH3.
 DOMAIN 627 802 Guanylate kinase-like.
 MOD_RES 673 673 Phosphotyrosine (By similarity).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Mental retardation; Phosphoprotein; Polymorphism; Reference proteome; Repeat; SH3 domain. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 817 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0043198; C:dendritic shaft; IEA:Compara.
 GO:0030426; C:growth cone; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0045202; C:synapse; IEA:Compara.
 GO:0005923; C:tight junction; IEA:Compara.
 GO:0004385; F:guanylate kinase activity; NAS:UniProtKB.
 GO:0019902; F:phosphatase binding; IDA:UniProtKB.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0001736; P:establishment of planar polarity; IEA:Compara.
 GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; NAS:UniProtKB.
 GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB.
 GO:0007268; P:synaptic transmission; TAS:Reactome. 

Interpro

 IPR008144; Guanylate_kin.
 IPR008145; Guanylate_kin/L-typ_Ca_channel.
 IPR020590; Guanylate_kinase_CS.
 IPR016313; M-assoc_guanylate_kinase.
 IPR019590; MAGUK_PEST_N.
 IPR027417; P-loop_NTPase.
 IPR001478; PDZ.
 IPR019583; PDZ_assoc.
 IPR001452; SH3_domain. 

Pfam

 PF00625; Guanylate_kin
 PF10608; MAGUK_N_PEST
 PF00595; PDZ
 PF10600; PDZ_assoc
 PF00018; SH3_1 

SMART

 SM00072; GuKc
 SM00228; PDZ
 SM00326; SH3 

PROSITE

 PS00856; GUANYLATE_KINASE_1
 PS50052; GUANYLATE_KINASE_2
 PS50106; PDZ
 PS50002; SH3 

PRINTS