CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032739
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lipoamide acyltransferase component of branched-chain alpha-keto dehyrogenase complex, putative 
Protein Synonyms/Alias
  
Gene Name
 TGVEG_011020 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Toxoplasma gondii 
NCBI Taxa ID
 5811 
Lysine Modification
Position
Peptide
Type
References
90IAQVELLKWHKGVGDacetylation[1]
219GRNGLITKEDVLKFLacetylation[2]
320LVAHTAKKYNCRPTIacetylation[2]
Reference
 [1] Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii.
 Jeffers V, Sullivan WJ Jr.
 Eukaryot Cell. 2012 Jun;11(6):735-42. [PMID: 22544907]
 [2] Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii.
 Xue B, Jeffers V, Sullivan WJ, Uversky VN.
 Mol Biosyst. 2013 Apr 5;9(4):645-57. [PMID: 23403842] 
Functional Description
  
Sequence Annotation
  
Keyword
 Acyltransferase; Complete proteome; Lipoyl; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 510 AA 
Protein Sequence
MLATRRVFSA SPRLACARAG IAQAFVPRPL APLTRLGAGC LPQRQLELNN APLVLPGKRC 60
LLTVSRPALA VKTFKLADIG EGIAQVELLK WHKGVGDHVE EMDELCEVQS DKAAVEITSR 120
FTGTIVKLHQ KEGMMVRIGA PLMDIDVEAG EDHAEEEEPE TKERPAPVSE PQAAASPSVG 180
AEASSTTFSA SPATRRFAKE KGVDLARVKG SGRNGLITKE DVLKFLESSQ VAAPAAQSPP 240
PAPAQGSFAG SPNAQPRAAP VVPQRPQRET TQVQLMGFSR AMVKSMNETV KVPQLNIGDE 300
YDITELTKMR ETLVAHTAKK YNCRPTITAF LIKAVSLALD ETPILNSKFN AATGDSYTQF 360
GSHNISVAID TPNGLVVPNI KNVQDLNVLE IQAELHRLQE LATANKLSPA DLQGGTISIS 420
NVGVISGTYV HALLFDGQAC IIGVGQARDL PRFVGKSGQA FDEDLVERRR IMTCAFTADH 480
RHCDGATVAR FNKRVKELLE NPAMMLLHLR 510 
Gene Ontology
 GO:0048037; F:cofactor binding; IEA:InterPro.
 GO:0043754; F:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity; IEA:EC.
 GO:0046949; P:fatty-acyl-CoA biosynthetic process; IEA:InterPro. 
Interpro
 IPR003016; 2-oxoA_DH_lipoyl-BS.
 IPR001078; 2-oxoacid_DH_actylTfrase.
 IPR000089; Biotin_lipoyl.
 IPR023213; CAT-like_dom.
 IPR004167; E3-bd.
 IPR015761; Lip_Acyl_TA.
 IPR011053; Single_hybrid_motif. 
Pfam
 PF00198; 2-oxoacid_dh
 PF00364; Biotin_lipoyl
 PF02817; E3_binding 
SMART
  
PROSITE
 PS50968; BIOTINYL_LIPOYL
 PS00189; LIPOYL 
PRINTS