UniProt Accession

 ZNF16_HUMAN; P17020; B3KXM4; D3DWP2; Q96FG0 

Genbank Protein ID

 AK127625; CH471162; CH471162; BC010996; X52340 

Genbank Nucleotide ID

 BAG54536.1; EAW82027.1; EAW82028.1; AAH10996.2; CAA36566.1 

Protein Name

 Zinc finger protein 16 

Protein Synonyms/Alias

 Zinc finger protein KOX9 

Gene Name

 ZNF16 

Gene Synonyms/Alias

 KOX9 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
487	QIIHTGEKPYRCSVC	acetylation	[1, 2, 3]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 May be involved in transcriptional regulation. 

Sequence Annotation

 ZN_FING 209 231 C2H2-type 1; degenerate.
 ZN_FING 237 259 C2H2-type 2; degenerate.
 ZN_FING 265 287 C2H2-type 3.
 ZN_FING 293 315 C2H2-type 4.
 ZN_FING 321 343 C2H2-type 5.
 ZN_FING 349 371 C2H2-type 6.
 ZN_FING 377 399 C2H2-type 7.
 ZN_FING 405 427 C2H2-type 8.
 ZN_FING 433 455 C2H2-type 9.
 ZN_FING 461 483 C2H2-type 10.
 ZN_FING 489 511 C2H2-type 11.
 ZN_FING 517 539 C2H2-type 12.
 ZN_FING 545 567 C2H2-type 13.
 ZN_FING 573 595 C2H2-type 14.
 ZN_FING 601 623 C2H2-type 15.
 ZN_FING 629 651 C2H2-type 16.
 ZN_FING 657 679 C2H2-type 17.
 MOD_RES 487 487 N6-acetyllysine.  

Keyword

 Acetylation; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 682 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

  

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS