UniProt Accession

 T22D1_HUMAN; Q15714; B3KRL7; B9EGI0; O00666; Q6AHX5; Q6IBU1; Q8NCN1; Q96JS5 

Genbank Protein ID

 U35048; D38585; AJ222700; D87061; AF256226; AB082525; AK091854; AK312345; CR456711; CR627459; AL138960; AL139184; AL139184; AL138960; AL356107; CH471075; BC000456; BC016867; BC069207; BC105277; BC136475; BC136482; BC146664; BC146679 

Genbank Nucleotide ID

 AAC50566.1; BAA07598.1; CAA10951.1; BAB46917.1; AAG53077.1; BAC02703.1; BAG52429.1; BAG35266.1; CAG32992.1; CAH10539.1; CAI12991.1; CAI12991.1; CAI16499.1; CAI16499.1; EAX08710.1; AAH00456.1; AAH16867.1; AAH69207.1; AAI05278.1; AAI36476.1; AAI36483.1; AAI46665.1; AAI46680.1 

Protein Name

 TSC22 domain family protein 1 

Protein Synonyms/Alias

 Cerebral protein 2; Regulatory protein TSC-22; TGFB-stimulated clone 22 homolog; Transforming growth factor beta-1-induced transcript 4 protein 

Gene Name

 TSC22D1 

Gene Synonyms/Alias

 KIAA1994; TGFB1I4; TSC22; hucep-2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
54	SVVAIDNKIEQAMDL	ubiquitination	[1, 2, 3, 4]
63	EQAMDLVKSHLMYAV	ubiquitination	[4]
87	QIKELIEKNSQLEQE	ubiquitination	[4]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter. 

Sequence Annotation

 REGION 1006 1027 Leucine-zipper.
 MOD_RES 263 263 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1073 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. 

Interpro

 IPR000580; TSC-22_Dip_Bun. 

Pfam

 PF01166; TSC22 

SMART

  

PROSITE

 PS01289; TSC22 

PRINTS