UniProt Accession

 MPP6_YEAST; P53725; D6W1J9 

Genbank Protein ID

 Z71639; BK006947 

Genbank Nucleotide ID

 CAA96303.1; DAA10565.1 

Protein Name

 M-phase phosphoprotein 6 homolog 

Protein Synonyms/Alias

 Exosome-associated RNA-binding protein MPP6 

Gene Name

 MPP6 

Gene Synonyms/Alias

 YNR024W; N3230 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
10	ANNGVTGKLSSRVMN	acetylation	[1]
128	DSGSRKRKFDEGEQN	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA) derived from intergenic regions and the ribosomal DNA spacer heterochromatin. Binds RNA. 

Sequence Annotation

 MOD_RES 42 42 Phosphoserine.
 MOD_RES 150 150 Phosphoserine.  

Keyword

 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 186 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0000176; C:nuclear exosome (RNase complex); IDA:SGD.
 GO:0008266; F:poly(U) RNA binding; IDA:SGD.
 GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0071031; P:nuclear mRNA surveillance of mRNA 3'-end processing; IGI:SGD.
 GO:0071030; P:nuclear mRNA surveillance of spliceosomal pre-mRNA splicing; IGI:SGD.
 GO:0071039; P:nuclear polyadenylation-dependent CUT catabolic process; IMP:SGD.
 GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; IGI:SGD. 

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