| Tag | Content |
|---|
| CPLM ID | CPLM-001392 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
Protein Synonyms/Alias | Brain cyclic nucleotide-gated channel 1; BCNG-1; Hyperpolarization-activated cation channel 2; HAC-2 |
Gene Name | Hcn1 |
Gene Synonyms/Alias | Bcng1; Hac2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 97 | MLQPGVNKFSLRMFG | ubiquitination | [1] | | 419 | LPADMRQKIHDYYEH | ubiquitination | [1] | | 535 | GEICLLTKGRRTASV | ubiquitination | [1] | | 586 | RLDRIGKKNSILLQK | ubiquitination | [1] | | 593 | KNSILLQKFQKDLNT | ubiquitination | [1] | | 596 | ILLQKFQKDLNTGVF | ubiquitination | [1] | | 612 | NQENEILKQIVKHDR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli. |
Sequence Annotation | NP_BIND 464 581 cAMP.
REGION 78 129 Involved in subunit assembly (By
MOD_RES 39 39 Phosphothreonine.
MOD_RES 69 69 Phosphoserine.
CARBOHYD 327 327 N-linked (GlcNAc...) (Probable). |
Keyword | 3D-structure; cAMP; cAMP-binding; Complete proteome; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Nucleotide-binding; Phosphoprotein; Potassium; Potassium channel; Potassium transport; Reference proteome; Sodium; Sodium channel; Sodium transport; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 910 AA |
Protein Sequence | MEGGGKPNSA SNSRDDGNSV FPSKAPATGP VAADKRLGTP PGGGAAGKEH GNSVCFKVDG 60
GGGEEPAGSF EDAEGPRRQY GFMQRQFTSM LQPGVNKFSL RMFGSQKAVE KEQERVKTAG 120
FWIIHPYSDF RFYWDLIMLI MMVGNLVIIP VGITFFTEQT TTPWIIFNVA SDTVFLLDLI 180
MNFRTGTVNE DSSEIILDPK VIKMNYLKSW FVVDFISSIP VDYIFLIVEK GMDSEVYKTA 240
RALRIVRFTK ILSLLRLLRL SRLIRYIHQW EEIFHMTYDL ASAVVRIFNL IGMMLLLCHW 300
DGCLQFLVPL LQDFPPDCWV SLNEMVNDSW GKQYSYALFK AMSHMLCIGY GAQAPVSMSD 360
LWITMLSMIV GATCYAMFVG HATALIQSLD SSRRQYQEKY KQVEQYMSFH KLPADMRQKI 420
HDYYEHRYQG KIFDEENILS ELNDPLREEI VNFNCRKLVA TMPLFANADP NFVTAMLSKL 480
RFEVFQPGDY IIREGAVGKK MYFIQHGVAG VITKSSKEMK LTDGSYFGEI CLLTKGRRTA 540
SVRADTYCRL YSLSVDNFNE VLEEYPMMRR AFETVAIDRL DRIGKKNSIL LQKFQKDLNT 600
GVFNNQENEI LKQIVKHDRE MVQAIPPINY PQMTALNCTS STTTPTSRMR TQSPPVYTAT 660
SLSHSNLHSP SPSTQTPQPS AILSPCSYTT AVCSPPIQSP LATRTFHYAS PTASQLSLMQ 720
QPQQQLPQSQ VQQTQTQTQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQPQTPG 780
SSTPKNEVHK STQALHNTNL TKEVRPLSAS QPSLPHEVST LISRPHPTVG ESLASIPQPV 840
AAVHSTGLQA GSRSTVPQRV TLFRQMSSGA IPPNRGVPPA PPPPAAVQRE SPSVLNTDPD 900
AEKPRFASNL 910 |
Gene Ontology | GO:0030424; C:axon; IDA:MGI. GO:0030425; C:dendrite; IDA:MGI. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0030552; F:cAMP binding; IEA:UniProtKB-KW. GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW. GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro. GO:0045176; P:apical protein localization; IMP:MGI. GO:0046549; P:retinal cone cell development; IMP:MGI. GO:0035725; P:sodium ion transmembrane transport; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |