UniProt Accession

 SYUA_RAT; P37377; P37378; Q53YM9 

Genbank Protein ID

 S73007; S73008; S73009; AF007758; AY550005; AY550006; BC087682 

Genbank Nucleotide ID

 AAB20688.1; AAB20689.1; AAB20690.1; AAC16026.1; AAS55694.1; AAS55695.1; AAH87682.1 

Protein Name

 Alpha-synuclein 

Protein Synonyms/Alias

  

Gene Name

 Snca 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
6	**MDVFMKGLSKAKE	acetylation	[1]
34	AEAAGKTKEGVLYVG	acetylation	[1]
34	AEAAGKTKEGVLYVG	ubiquitination	[2]
45	LYVGSKTKEGVVHGV	acetylation	[1]
96	AAATGFVKKDQMGKG	acetylation	[1]
96	AAATGFVKKDQMGKG	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 May be involved in the regulation of dopamine release and transport. 

Sequence Annotation

 REPEAT 20 30 1.
 REPEAT 31 41 2.
 REPEAT 42 56 3; approximate.
 REPEAT 57 67 4.
 REGION 20 67 4 X 11 AA tandem repeats of [EGS]-K-T-K-
 METAL 2 2 Copper (By similarity).
 METAL 50 50 Copper (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 125 125 Phosphotyrosine; by FYN (By similarity).
 MOD_RES 129 129 Phosphoserine; by PLK2 (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Copper; Cytoplasm; Direct protein sequencing; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 140 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0005938; C:cell cortex; IEA:Compara.
 GO:0030659; C:cytoplasmic vesicle membrane; IDA:BHF-UCL.
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0043205; C:fibril; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IDA:RGD.
 GO:0030426; C:growth cone; IDA:RGD.
 GO:0016234; C:inclusion body; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:BHF-UCL.
 GO:0005640; C:nuclear outer membrane; IDA:RGD.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0031092; C:platelet alpha granule membrane; IEA:Compara.
 GO:0005840; C:ribosome; IDA:RGD.
 GO:0005791; C:rough endoplasmic reticulum; IDA:RGD.
 GO:0008021; C:synaptic vesicle; IDA:RGD.
 GO:0043195; C:terminal bouton; IDA:RGD.
 GO:0050544; F:arachidonic acid binding; IEA:Compara.
 GO:0048487; F:beta-tubulin binding; IDA:RGD.
 GO:0005509; F:calcium ion binding; IEA:Compara.
 GO:0005507; F:copper ion binding; ISS:UniProtKB.
 GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IEA:Compara.
 GO:0008198; F:ferrous iron binding; IEA:Compara.
 GO:0000287; F:magnesium ion binding; IEA:Compara.
 GO:0008017; F:microtubule binding; IDA:UniProtKB.
 GO:0016491; F:oxidoreductase activity; IEA:Compara.
 GO:0005543; F:phospholipid binding; IDA:RGD.
 GO:0047485; F:protein N-terminus binding; IDA:RGD.
 GO:0008270; F:zinc ion binding; IEA:Compara.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0008344; P:adult locomotory behavior; IEA:Compara.
 GO:0007568; P:aging; IEP:RGD.
 GO:0048148; P:behavioral response to cocaine; IMP:RGD.
 GO:0071280; P:cellular response to copper ion; IEA:Compara.
 GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEP:RGD.
 GO:0034599; P:cellular response to oxidative stress; IEA:Compara.
 GO:0042416; P:dopamine biosynthetic process; IEA:Compara.
 GO:0006631; P:fatty acid metabolic process; IEA:Compara.
 GO:0060291; P:long-term synaptic potentiation; IEA:Compara.
 GO:0001774; P:microglial cell activation; IEA:Compara.
 GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Compara.
 GO:0007006; P:mitochondrial membrane organization; IEA:Compara.
 GO:0045963; P:negative regulation of dopamine metabolic process; IMP:BHF-UCL.
 GO:0051585; P:negative regulation of dopamine uptake involved in synaptic transmission; IEA:Compara.
 GO:0045920; P:negative regulation of exocytosis; IEA:Compara.
 GO:0035067; P:negative regulation of histone acetylation; IEA:Compara.
 GO:0031115; P:negative regulation of microtubule polymerization; IEA:Compara.
 GO:0032769; P:negative regulation of monooxygenase activity; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IMP:RGD.
 GO:0051622; P:negative regulation of norepinephrine uptake; IEA:Compara.
 GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IEA:Compara.
 GO:0001933; P:negative regulation of protein phosphorylation; IMP:BHF-UCL.
 GO:0051612; P:negative regulation of serotonin uptake; IEA:Compara.
 GO:0070495; P:negative regulation of thrombin receptor signaling pathway; IEA:Compara.
 GO:0032410; P:negative regulation of transporter activity; IEA:Compara.
 GO:0006638; P:neutral lipid metabolic process; IEA:Compara.
 GO:0006644; P:phospholipid metabolic process; IEA:Compara.
 GO:0045807; P:positive regulation of endocytosis; IEA:Compara.
 GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IEA:Compara.
 GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Compara.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Compara.
 GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IEA:Compara.
 GO:0001921; P:positive regulation of receptor recycling; IEA:Compara.
 GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IEA:Compara.
 GO:0031648; P:protein destabilization; IEA:Compara.
 GO:0031623; P:receptor internalization; IEA:Compara.
 GO:0050812; P:regulation of acyl-CoA biosynthetic process; IEA:Compara.
 GO:0014059; P:regulation of dopamine secretion; IEA:Compara.
 GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IEA:Compara.
 GO:0014048; P:regulation of glutamate secretion; IEA:Compara.
 GO:0040012; P:regulation of locomotion; IEA:Compara.
 GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Compara.
 GO:0043030; P:regulation of macrophage activation; IEA:Compara.
 GO:0010517; P:regulation of phospholipase activity; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0034341; P:response to interferon-gamma; IEA:Compara.
 GO:0070555; P:response to interleukin-1; IEA:Compara.
 GO:0010040; P:response to iron(II) ion; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0032026; P:response to magnesium ion; IEA:Compara.
 GO:0050808; P:synapse organization; IEA:Compara.
 GO:0001963; P:synaptic transmission, dopaminergic; IEA:Compara.
 GO:0048488; P:synaptic vesicle endocytosis; IEA:Compara. 

Interpro

 IPR001058; Synuclein.
 IPR002460; Synuclein_alpha. 

Pfam

 PF01387; Synuclein 

SMART

  

PROSITE

  

PRINTS

 PR01212; ASYNUCLEIN.
 PR01211; SYNUCLEIN.