CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044344
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Probable ATP-dependent RNA helicase DDX41 
Protein Synonyms/Alias
  
Gene Name
 DDX41 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
348RLMDLLQKKMVSLDIubiquitination[1]
349LMDLLQKKMVSLDICubiquitination[1]
399FSATMPKKIQNFAKSubiquitination[1]
410FAKSALVKPVTINVGubiquitination[1]
460VLIFAEKKADVDAIHubiquitination[1, 2]
484AVAIHGGKDQEERTKubiquitination[1]
491KDQEERTKAIEAFREubiquitination[1]
556IATTFINKACDESVLubiquitination[1]
574KALLLEAKQKVPPVLubiquitination[1]
615HRITDCPKLEAMQTKubiquitination[1]
622KLEAMQTKQVSNIGRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 640 AA 
Protein Sequence
RREARPRACG SGREEGSRPC LTGVCLQRAR TDEVPAGGSR SEAEDEDDED YVPYVPLRQR 60
RQLLLQKLLQ RRRKGAAEEE QQDSGSEPRG DEDDIPLGPQ SNVSLLDQHQ HLKEKAEARK 120
ESAKEKQLKE EEKILESVAE GRALMSVKEM AKGITYDDPI KTSWTPPRYV LSMSEERHER 180
VRKKYHILVE GDGIPPPIKS FKEMKFPAAI LRGLKKKGIH HPTPIQIQGI PTILSGRDMI 240
GIAFTGSGKT LVFTLPVIMF CLEQEKRLPF SKREGPYGLI ICPSRELARQ THGILEYYCR 300
LLQEDSSPLL RCALCIGGMS VKEQMETIRH GVHMMVATPG RLMDLLQKKM VSLDICRYLA 360
LDEADRMIDM GFEGDIRTIF SYFKGQRQTL LFSATMPKKI QNFAKSALVK PVTINVGRAG 420
AASLDVIQEV EYVKEEAKMV YLLECLQKTP PPVLIFAEKK ADVDAIHEYL LLKGVEAVAI 480
HGGKDQEERT KAIEAFREGK KDVLVATDVA SKGLDFPAIQ HVINYDMPEE IENYVHRIGR 540
TGRSGNTGIA TTFINKACDE SVLMDLKALL LEAKQKVPPV LQVLHCGDES MLDIGGERGC 600
AFCGGLGHRI TDCPKLEAMQ TKQVSNIGRK DYLAHSSMDF 640 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR014014; RNA_helicase_DEAD_Q_motif.
 IPR001878; Znf_CCHC. 
Pfam
 PF00270; DEAD
 PF00271; Helicase_C 
SMART
 SM00487; DEXDc
 SM00490; HELICc
 SM00343; ZnF_C2HC 
PROSITE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51195; Q_MOTIF 
PRINTS