UniProt Accession

 RIBB_ECOLI; P0A7J0; P24199; Q2M9F9 

Genbank Protein ID

 M64472; M77129; X66720; U28377; U00096; AP009048 

Genbank Nucleotide ID

 AAA23996.1; AAA71879.1; CAA47252.1; AAA69209.1; AAC76077.1; BAE77097.1 

Protein Name

 3,4-dihydroxy-2-butanone 4-phosphate synthase 

Protein Synonyms/Alias

 DHBP synthase 

Gene Name

 ribB 

Gene Synonyms/Alias

 htrP; b3041; JW3009 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
127	AAIADGAKPSDLNRP	acetylation	[1]
194	ECIEFANKHNMALVT	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. 

Sequence Annotation

 REGION 37 38 Substrate binding (By similarity).
 REGION 150 154 Substrate binding (By similarity).
 METAL 38 38 Magnesium or manganese 1 (By similarity).
 METAL 38 38 Magnesium or manganese 2 (By similarity).
 METAL 153 153 Magnesium or manganese 2 (By similarity).
 BINDING 42 42 Substrate (By similarity).
 BINDING 174 174 Substrate (By similarity).  

Keyword

 3D-structure; Cell membrane; Complete proteome; Direct protein sequencing; Lyase; Magnesium; Manganese; Membrane; Metal-binding; Reference proteome; Riboflavin biosynthesis; Stress response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 217 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0008686; F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity; IDA:EcoCyc.
 GO:0000287; F:magnesium ion binding; IDA:EcoCyc.
 GO:0030145; F:manganese ion binding; IEA:HAMAP.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW.
 GO:0009231; P:riboflavin biosynthetic process; IEA:HAMAP. 

Interpro

 IPR017945; DHBP_synth_RibB-like_a/b_dom.
 IPR000422; DHBP_synthase_RibB. 

Pfam

 PF00926; DHBP_synthase 

SMART

  

PROSITE

  

PRINTS