| Tag | Content |
|---|
| CPLM ID | CPLM-020398 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tether containing UBX domain for GLUT4 |
Protein Synonyms/Alias | Alveolar soft part sarcoma chromosomal region candidate gene 1 protein; Alveolar soft part sarcoma locus; Renal papillary cell carcinoma protein 17; UBX domain-containing protein 9 |
Gene Name | ASPSCR1 |
Gene Synonyms/Alias | ASPL; RCC17; TUG; UBXD9; UBXN9 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 75 | ANLPNNAKLEMVPAS | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by METTL21D. |
Sequence Annotation | DOMAIN 386 462 UBX.
REGION 317 380 Interaction with GLUT4 (By similarity).
MOD_RES 500 500 Phosphoserine. |
Keyword | Alternative splicing; Chromosomal rearrangement; Complete proteome; Cytoplasm; Membrane; Nucleus; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 553 AA |
Protein Sequence | MAAPAGGGGS AVSVLAPNGR RHTVKVTPST VLLQVLEDTC RRQDFNPCEY DLKFQRSVLD 60
LSLQWRFANL PNNAKLEMVP ASRSREGPEN MVRIALQLDD GSRLQDSFCS GQTLWELLSH 120
FPQIRECLQH PGGATPVCVY TRDEVTGEAA LRGTTLQSLG LTGGSATIRF VMKCYDPVGK 180
TPGSLGSSAS AGQAAASAPL PLESGELSRG DLSRPEDADT SGPCCEHTQE KQSTRAPAAA 240
PFVPFSGGGQ RLGGPPGPTR PLTSSSAKLP KSLSSPGGPS KPKKSKSGQD PQQEQEQERE 300
RDPQQEQERE RPVDREPVDR EPVVCHPDLE ERLQAWPAEL PDEFFELTVD DVRRRLAQLK 360
SERKRLEEAP LVTKAFREAQ IKEKLERYPK VALRVLFPDR YVLQGFFRPS ETVGDLRDFV 420
RSHLGNPELS FYLFITPPKT VLDDHTQTLF QANLFPAALV HLGAEEPAGV YLEPGLLEHA 480
ISPSAADVLV ARYMSRAAGS PSPLPAPDPA PKSEPAAEEG ALVPPEPIPG TAQPVKRSLG 540
KVPKWLKLPA SKR 553 |
Gene Ontology | GO:0005829; C:cytosol; IEA:Compara. GO:0019898; C:extrinsic to membrane; IEA:Compara. GO:0009898; C:internal side of plasma membrane; IEA:Compara. GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara. GO:0012506; C:vesicle membrane; IEA:Compara. GO:0016044; P:cellular membrane organization; TAS:Reactome. GO:0042593; P:glucose homeostasis; IEA:Compara. GO:0006886; P:intracellular protein transport; IEA:Compara. GO:0046324; P:regulation of glucose import; IEA:Compara. |
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