CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015490
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RNA-binding protein MEX3B 
Protein Synonyms/Alias
 RING finger and KH domain-containing protein 3; RING finger protein 195 
Gene Name
 MEX3B 
Gene Synonyms/Alias
 KIAA2009; RKHD3; RNF195 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
201IVTPSRDKEPVFEVTubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 RNA-binding protein. May be involved in post- transcriptional regulatory mechanisms. 
Sequence Annotation
 DOMAIN 66 127 KH 1.
 DOMAIN 160 221 KH 2.
 ZN_FING 518 558 RING-type.
 MOD_RES 462 462 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 569 AA 
Protein Sequence
MPSSLFADLE RNGSGGGGGG SSGGGETLDD QRALQLALDQ LSLLGLDSDE GASLYDSEPR 60
KKSVNMTECV PVPSSEHVAE IVGRQGCKIK ALRAKTNTYI KTPVRGEEPV FVVTGRKEDV 120
AMARREIISA AEHFSMIRAS RNKNTALNGA VPGPPNLPGQ TTIQVRVPYR VVGLVVGPKG 180
ATIKRIQQQT HTYIVTPSRD KEPVFEVTGM PENVDRAREE IEAHIALRTG GIIELTDEND 240
FHANGTDVGF DLHHGSGGSG PGSLWSKPTP SITPTPGRKP FSSYRNDSSS SLGSASTDSY 300
FGGGTSSSAA ATQRLADYSP PSPALSFAHN GNNNNNGNGY TYTAGGEASV PSPDGCPELQ 360
PTFDPAPAPP PGAPLIWAQF ERSPGGGPAA PVSSSCSSSA SSSASSSSVV FPGGGASAPS 420
NANLGLLVHR RLHPGTSCPR LSPPLHMAPG AGEHHLARRV RSDPGGGGLA YAAYANGLGA 480
QLPGLQPSDT SGSSSSSSSS SSSSSSSSGL RRKGSRDCSV CFESEVIAAL VPCGHNLFCM 540
ECANRICEKS EPECPVCHTA VTQAIRIFS 569 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0000932; C:cytoplasmic mRNA processing body; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005509; F:calcium ion binding; ISS:UniProtKB.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0046777; P:protein autophosphorylation; ISS:UniProtKB. 
Interpro
 IPR004087; KH_dom.
 IPR004088; KH_dom_type_1.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00013; KH_1 
SMART
 SM00322; KH
 SM00184; RING 
PROSITE
 PS50084; KH_TYPE_1
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS