CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021936
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Chorion-specific transcription factor GCMa 
Protein Synonyms/Alias
 hGCMa; GCM motif protein 1; Glial cells missing homolog 1 
Gene Name
 GCM1 
Gene Synonyms/Alias
 GCMA 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
156KGEHDHPKPETKLEAsumoylation[1]
367AGNLYEEKVHVDFNSacetylation[2]
406QQYSLPSKSSKWDFEacetylation[2]
409SLPSKSSKWDFEEEMacetylation[2]
Reference
 [1] Small ubiquitin-like modifier modification regulates the DNA binding activity of glial cell missing Drosophila homolog a.
 Chou CC, Chang C, Liu JH, Chen LF, Hsiao CD, Chen H.
 J Biol Chem. 2007 Sep 14;282(37):27239-49. [PMID: 17646165]
 [2] Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa.
 Chang CW, Chuang HC, Yu C, Yao TP, Chen H.
 Mol Cell Biol. 2005 Oct;25(19):8401-14. [PMID: 16166624] 
Functional Description
 Transcription factor that is necessary for placental development. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. 
Sequence Annotation
 DNA_BIND 14 169 GCM.
 METAL 76 76 Zinc 1 (By similarity).
 METAL 82 82 Zinc 2 (By similarity).
 METAL 86 86 Zinc 2 (By similarity).
 METAL 113 113 Zinc 2 (By similarity).
 METAL 116 116 Zinc 2 (By similarity).
 METAL 125 125 Zinc 1 (By similarity).
 METAL 152 152 Zinc 1 (By similarity).
 METAL 154 154 Zinc 1 (By similarity).  
Keyword
 Complete proteome; Developmental protein; DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription; Transcription regulation; Ubl conjugation; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 436 AA 
Protein Sequence
MEPDDFDSED KEILSWDIND VKLPQNVKKT DWFQEWPDSY AKHIYSSEDK NAQRHLSSWA 60
MRNTNNHNSR ILKKSCLGVV VCGRDCLAEE GRKIYLRPAI CDKARQKQQR KRCPNCDGPL 120
KLIPCRGHGG FPVTNFWRHD GRFIFFQSKG EHDHPKPETK LEAEARRAMK KVNTAPSSVS 180
LSLKGSTETR SLPGETQSQG SLPLTWSFQE GVQLPGSYSG HLIANTPQQN SLNDCFSFSK 240
SYGLGGITDL TDQTSTVDPM KLYEKRKLSS SRTYSSGDLL PPSASGVYSD HGDLQAWSKN 300
AALGRNHLAD NCYSNYPFPL TSWPCSFSPS QNSSEPFYQQ LPLEPPAAKT GCPPLWPNPA 360
GNLYEEKVHV DFNSYVQSPA YHSPQEDPFL FTYASHPHQQ YSLPSKSSKW DFEEEMTYLG 420
LDHCNNDMLL NLCPLR 436 
Gene Ontology
 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:Compara.
 GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
 GO:0060018; P:astrocyte fate commitment; IEA:Compara.
 GO:0060670; P:branching involved in labyrinthine layer morphogenesis; IEA:Compara.
 GO:0060706; P:cell differentiation involved in embryonic placenta development; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR003902; Tscrpt_reg_GCM_motif. 
Pfam
 PF03615; GCM 
SMART
  
PROSITE
 PS50807; GCM 
PRINTS